Renal hypertrophy and hyperfiltration is enhanced in early-acquired compared to a congenital solitary function kidney model in sheep.

A congenital solitary functioning kidney (C-SFK) or an early acquired SFK (EA-SFK), due to childhood unilateral nephrectomy (unix), increases the risk of hypertension and kidney disease early in life. Evidence suggests that children with an EA-SFK may have a higher risk of future kidney disease compared to those with a C-SFK, but the precise underlying mechanisms need further investigation. C-SFK was induced by fetal unix at 100 days gestation (term=150 days) in male sheep fetuses and a sham procedure was performed. At 1 month of age, EA-SFK was induced by unix in male lambs. At 8 months of age total kidney weight was similar in all groups due to marked hypertrophy in the C-SFK and EA-SFK groups. Blood pressure was similar in EA-SFK and sham groups but ~12 mmHg higher in the C-SFK group compared with sham. Compared with the sham group, glomerular filtration rate (GFR) was ~9% less in the EA-SFK group and ~26% less in the C-SFK. GFR was ~23% greater in EA-SFK compared with the C-SFK group. Albuminuria was 67% greater in C-SFK sheep but similar in the EA-SFK group compared with sham sheep. However, like the C-SFK group, the renal blood flow response to nitric oxide blockade was attenuated in the EA-SFK group compared with sham. In conclusion, longer-term studies are needed to determine whether the greater hyperfiltration and disturbed vasodilator balance observed in EA-SFK sheep will cause an accelerated decline in renal function with aging.