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http://dx.doi.org/10.1001/jamaoncol.2024.7051 | DOI Listing |
Front Immunol
March 2025
Fundación Española para el Estudio y Terapéutica de la Enfermedad de Gaucher y otras lisosomales (FEETEG), Zaragoza, Spain.
Background: SARS-CoV-2 infection activates macrophages and induces the release of neutrophil extracellular traps (NETs). Excess NETs is linked to inflammatory and thrombotic complications observed in COVID-19.
Aim: To explore the impact of NETs and macrophage activation on SARS-CoV-2-infected patients who developed complications.
Front Immunol
March 2025
Department of Digestive Endoscopy, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Background: Esophageal squamous cell carcinoma (ESCC) represents a frequent cancer with a poor prognosis. Altered glucose metabolism contributes factor to ESCC progression. In our previous study, signal sequence receptor subunit delta (SSR4) was included in an ESCC prognostic model; however, the mechanisms underlying SSR4 implication in ESCC remain ambiguous.
View Article and Find Full Text PDFSheng Li Xue Bao
February 2025
Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
The current study aimed to clarify the roles of apolipoprotein A5 (ApoA5) and milk fat globule-epidermal growth factor 8 (Mfge8) in regulating myocardial lipid deposition and the regulatory relationship between them. The serum levels of ApoA5 and Mfge8 in obese and healthy people were compared, and the obesity mouse model induced by the high-fat diet (HFD) was established. In addition, primary cardiomyocytes were purified and identified from the hearts of suckling mice.
View Article and Find Full Text PDFDiabetologia
March 2025
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Aims/hypothesis: Components of the insulin processing and secretion pathways remain incompletely understood. Here, we examined a genome-wide association study (GWAS) signal for plasma proinsulin levels. Lead GWAS variant rs150781447-T encodes an Arg279Cys substitution in TBC1 domain family member 30 (TBC1D30), but no role for this protein in insulin processing or secretion has been established previously.
View Article and Find Full Text PDFNeurobiol Dis
March 2025
Neurodegenerative Diseases Unit, Fondazione Ca' Granda, IRCSS Ospedale Maggiore Policlinico, Milan, Italy; Dept of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; Neurodegenerative Diseases Unit, Fondazione Ca' Granda, IRCSS Ospedale Maggiore Policlinico, Milan, Italy.
Behavioral variant of Frontotemporal Dementia (bvFTD) and Bipolar Disorder (BD) share overlapping symptoms, complicating diagnosis. BvFTD, especially linked to C9orf72 expansions, often mimics BD, highlighting the need for reliable biomarkers. This study aimed to differentiate bvFTD from BD using miRNA profiles in neural-enriched extracellular vesicles (NEVs).
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