The treatment of bone defects presents significant challenges in clinical practice. Guided bone regeneration (GBR) strategies offer a new approach, but existing commercial GBR membranes still lack optimal barrier and osteogenic functions. This study presents the design of a Janus fibrous membrane using classic amphiphilic block copolymers and gelatin methacryloyl containing unsaturated double bonds through a gradient electrospinning process. Specifically, by controlling electrospinning parameters, self-assembly of block copolymers, and secondary photo-cross-linking, differential composition, topological structure, and properties between different layers were achieved, thereby realizing synergistic physiological barrier and repair-promoting functions. By leveraging the Janus effect, it effectively blocks the adverse effects of soft tissue cell ingrowth on bone repair while guiding osteogenic cell proliferation and differentiation. Furthermore, the membrane's functionality is optimized by incorporating the antimicrobial component ε-poly-l-lysine and the osteogenic component niobium. In vivo studies demonstrate the membrane's excellent biocompatibility, antibacterial activity, and remarkable bone regeneration potential in both normal and infectious bone defect animal models. The developed Janus fibrous membrane serves as a versatile platform for biomedical applications, offering the vast potential to effectively address the limitations of current GBR membranes in clinical bone defect treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsami.4c18965 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Asymmetric Janus composite films with superior humidity regulation capabilities for the efficient preservation of strawberry fruit.
Food Chem
March 2025
College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018, Shandong, PR China; Key Laboratory of Agricultural Membrane Application of Ministry of Agriculture and Rural Affairs, Taian 271018, Shandong, PR China. Electronic address:
This study aims to report the limitations of single-layer film packaging to control relative humidity and preventing water vapor condensation within packaging systems. It introduces the development of an asymmetrically structured Janus humidity-regulated composite film. The composite film consists of an inner active layer made of polyvinyl alcohol/chitosan (PVA/CS) with a fibrous structure, and an outer barrier layer composed of PVA with a dense configuration.
View Article and Find Full Text PDFSynergistic Functions of the Janus Fibrous Membrane for Enhanced Bone Repair.
ACS Appl Mater Interfaces
March 2025
Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, China.
The treatment of bone defects presents significant challenges in clinical practice. Guided bone regeneration (GBR) strategies offer a new approach, but existing commercial GBR membranes still lack optimal barrier and osteogenic functions. This study presents the design of a Janus fibrous membrane using classic amphiphilic block copolymers and gelatin methacryloyl containing unsaturated double bonds through a gradient electrospinning process.
View Article and Find Full Text PDFJanus flame-retardant polyester fabric with one-way water transfer for fog collection: Influence of plasma duration, aluminum phosphate, and TiO nanoparticles.
Heliyon
February 2025
Department of Textile Engineering, Yazd University, Yazd, Iran.
Significant efforts have been made to create Janus fabrics including designing their structure, employing electrospraying and electrospinning, and applying chemical and physical surface treatments to enhance the effective and directed transport of water. In this paper, a Janus industrial fabric with desirable properties such as one-way water transfer, fog collection, mechanical durability, and flame resistance was prepared. The creation of superhydrophobic surfaces on polyester fabrics involved the attachment of titanium dioxide nanoparticles (NTO) onto the fabric using aluminum phosphate (AP) adhesive and then coating with fluoroacrylate polymer (F) as a low-energy surface material.
View Article and Find Full Text PDFSkin-inspired elastomer-hydrogel Janus fibrous membrane creates a superior pro-regenerative microenvironment toward complete skin regeneration.
Biomater Adv
May 2025
School of Medicine, South China University of Technology, Guangzhou 510006, China; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China. Electronic address:
The complete regeneration of deep cutaneous wounds remains a challenge. Development of advanced biomaterials that more closely resemble the natural healing environments of skin is a promising strategy. In the present study, inspired by the human skins, an elastomer-hydrogel bilayer fibrous membrane was fabricated for cutaneous wound healing.
View Article and Find Full Text PDFMetal-Phenolic Network (MPN) Modified Janus Fibrous Hydrogel Scaffold for Infected Diabetic Wound Healing.
ACS Appl Mater Interfaces
February 2025
School of Nano-Tech and Nano-Bionics, University of Science and Technology of China (USTC), Hefei 230026, P. R. China.
Management of infected diabetic wounds with large amounts of biofluid is challenging to treat due to localized edema-induced ischemia. Traditional hydrophilic dressings retain wound exudate, raise bacterial infection, and hinder wound healing. Herein, a multifunctional double-layer Janus fibrous hydrogel with a hydrophobic and superhydrophilic potential was designed to accelerate the healing of infected diabetic wounds.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!