In this paper, a model for simulating the shot noise power and the electronic noise power of a balanced homodyne detector (BHD) using cascaded low noise amplifiers (LNAs) is presented. Moreover, the factors influencing the enhancement of BHD gain flatness are analyzed. Based on these theories, a BHD with a large clearance between shot noise and electronic noise, along with a flat broadband frequency response, is designed using LNAs and an optimized printed circuit board design. According to the experimental measurements, the bandwidth for 1 dB flatness reaches 1.4 GHz with the -3 dB bandwidth extending up to 1.55 GHz. With a 4 mW optical signal input, a signal-to-noise ratio of 12 dB is obtained at 1 GHz. The BHD exhibits excellent linearity for shot noise output up to an 8 mW optical signal input and a tested common mode rejection ratio of 63 dB. This developed BHD is well-suited for applications in high-speed continuous variable quantum key distribution and quantum random number generation.
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http://dx.doi.org/10.1063/5.0239073 | DOI Listing |
Anal Chem
March 2025
Department of Chemistry, Atomic and Mass Spectrometry - A&MS Research Group, Ghent University, Campus Sterre, Krijgslaan 281-S12, Ghent 9000, Belgium.
Novel low-dispersion ablation cell designs and highly efficient aerosol transport systems have enabled fast elemental mapping using laser ablation-ICP-mass spectrometry (LA-ICP-MS) at high spatial resolution and its application in various research fields. Nowadays, the fastest low-dispersion setups enable narrow single pulse responses (SPR, duration of the transient signal observed upon a single laser shot), which enhance the signal-to-noise ratio and boost the pixel acquisition rate attainable in elemental mapping applications. In this work, the analytical performance of a nanosecond 193 nm ArF* excimer-based kHz laser in combination with a low-dispersion tube-type ablation cell, coupled to an ICP-mass spectrometer equipped with a time-of-flight (ToF) analyzer, was evaluated.
View Article and Find Full Text PDFSci Rep
March 2025
Japan Broadcasting Corporation (NHK), Science and Technology Research Laboratories, Kinuta 1-10-11, Setagaya, Tokyo, 157-8510, Japan.
Incoherent digital holography (IDH) is a passive holographic 3D imaging technique under spatially incoherent light. Single-shot recording with high light-utilization efficiency and high spatial resolution is a challenge in IDH. Herein, we propose a single-shot three-step phase-shifting IDH system with a 1D phase grating that has a line-and-space structure.
View Article and Find Full Text PDFObjective: The purpose of this work is to investigate the feasibility of high-resolution whole-brain diffusion tensor imaging (DTI) using a rapid single-slab 3D pseudo-random EPI encoding strategy with physical constraints.
Methods: A spin-echo-based diffusion-weighted imaging was modified to incorporate both single-slab 3D segmented EPI for high-resolution diffusion imaging and unsegmented EPI with short readouts for segment-specific motion-induced phase navigation. A physically constrained, segment-wise grouped phase encoding strategy is introduced, yielding a rapid, pseudo-random traversal of -space with smooth signal transition in local neighborhood even in the presence of magnetic field inhomogeneities.
Adv Sci (Weinh)
March 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Discovering therapeutic molecules requires the integration of both phenotype-based drug discovery (PDD) and target-based drug discovery (TDD). However, this integration remains challenging due to the inherent heterogeneity, noise, and bias present in biomedical data. In this study, Knowledge-Guided Drug Relational Predictor (KGDRP), a graph representation learning approach is developed that effectively integrates multimodal biomedical data, including network data containing biological system information, gene expression data, and sequence data that incorporates chemical molecular structures, all within a heterogeneous graph (HG) structure.
View Article and Find Full Text PDFLight Sci Appl
March 2025
Dipartimento di Fisica, Università degli Studi di Trieste, Trieste, Italy.
Measuring fluctuations in matter's low-energy excitations is the key to unveiling the nature of the non-equilibrium response of materials. A promising outlook in this respect is offered by spectroscopic methods that address matter fluctuations by exploiting the statistical nature of light-matter interactions with weak few-photon probes. Here we report the first implementation of ultrafast phase randomized tomography, combining pump-probe experiments with quantum optical state tomography, to measure the ultrafast non-equilibrium dynamics in complex materials.
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