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Scoping literature review to identify candidate domains for the OMERACT Systemic Lupus Erythematosus core outcome set.
Semin Arthritis Rheum
February 2025
Institute of Medical Science, University of Toronto, Toronto, Canada; Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada; University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, ON, Canada. Electronic address:
Objective: To identify candidate Systemic Lupus Erythematosus (SLE) domains from the literature for consideration towards the development of the SLE Core Outcome Set.
Methods: This was a comprehensive scoping literature review of SLE clinical trials and systematic reviews published since 2010. Studies were identified from 5 databases and were screened for eligibility.
Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation.
Lancet Oncol
March 2025
Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.
Radiotherapy both promotes and antagonises tumour immune recognition. Some clinical studies show improved patient outcomes when immunotherapies are integrated with radiotherapy. Safe, greater than additive, clinical response to the combination is limited to a subset of patients, however, and how radiotherapy can best be combined with immunotherapies remains unclear.
View Article and Find Full Text PDFDecrypting the messages in the matrix: The proceedings of a symposium on dairy food matrix science and public health opportunities.
Crit Rev Food Sci Nutr
March 2025
National Dairy Council, Rosemont, Illinois, USA.
Although food matrix research is still in its infancy, there is an emerging understanding of the important role of the food matrix on human nutrition and physiology, as well as for public health. This understanding has largely been propelled forward by research involving different milk and dairy food matrices which has revealed that in addition to their distinct array of nutrients and bioactive compounds, milk and dairy foods also contain complex food matrix microstructures that act as nutrient and bioactive delivery systems that set them apart from the other food groups. Due to these distinct food matrix properties, milk and dairy foods may be uniquely positioned to help Americans meet many of their nutrition and health needs.
View Article and Find Full Text PDFProceedings of the American College of Surgeons Surgical Adhesions Improvement Project Summit.
J Am Coll Surg
February 2025
Department of Surgery, UCLA, Los Angeles, CA (Ko).
Assessing adverse event burden in chronic lymphocytic leukemia treatment regimens: what's best for patient quality of life?
Expert Opin Drug Saf
February 2025
Department of Hematology, Medical University of Lodz, Lodz, Poland.
Introduction: In recent years, chronic lymphocytic leukemia (CLL) treatment has changed dramatically. Chemoimmunotherapy with fludarabine/cladribine, cyclophosphamide and rituximab have been almost completely replaced by targeted therapies with small molecules such as Bruton's tyrosine kinase inhibitors or B-cell lymphoma 2 (BCL-2) antagonists. However, few studies have assessed the impact of novel therapies on patient quality of life (QoL).
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