Ischemic stroke is a common disease that can stem from multiple different causes, some of which are uncommon. A 43 year old woman with a history of systemic lupus erythematosus and antiphospholipid syndrome visited the emergency department due to dysarthria and was diagnosed with ischemic stroke. Transesophageal echocardiogram showed a mass on the mitral valve. After further workup, she was diagnosed with Libman-Sacks endocarditis, which is caused by endothelium damage along with hypercoagulability, and can form due to systemic lupus erythematosus or antiphospholipid syndrome. Libman-Sacks endocarditis is a nonbacterial thrombotic endocarditis and thromboembolism is rare. It is treated with anticoagulation. It is also important to treat the underlying cause of the endocarditis.
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Corrigendum to "ROTEM and von Willebrand Factor in COVID patients presenting with acute ischemic stroke: A case series: ROTEM and von Willebrand Factor in COVID-19 Related Stroke" [Journal of Stroke and Cerebrovascular Diseases, Volume 33 (11), 2024 Nov 1, p.107894].
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Department of Neurology, Division of Neurocritical Care, University of North Carolina, Chapel Hill, NC, USA. Electronic address:
Periprocedural and Long-Term Outcomes of Carotid Stent Placement in Patients with Very Severe Carotid Artery Stenosis vs Carotid Near Occlusion with Full Collapse: A Propensity Score Matching Analysis.
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Department of Vascular Surgery, Zhongshan Hospital, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China. Electronic address:
Purpose: To compare the periprocedural and 5-year outcomes between patients with very severe stenosis (80%-99% stenosis) and those with carotid near occlusion (CNO) with full collapse.
Materials And Methods: Data from patients with very severe stenosis and CNO with full collapse who underwent carotid artery stenting (CAS) at our center were retrospectively analyzed from January 2018 to December 2021. Unmatched and propensity score-matched (PSM) comparisons of periprocedural complications and 5-year follow-up rates for in-stent restenosis, ipsilateral ischemic stroke, myocardial infarction (MI), and mortality were conducted between the two groups.
Netrin-1 binding to UNC5b improves post-stroke neuronal ferroptosis via AMPK-BACH1 pathway.
Eur J Pharmacol
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Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, 510080 China. Electronic address:
Ferroptosis contributes to neuronal destruction after ischemic stroke which may be improved by inhibiting BTB domain and CNC homologue 1 (BACH1), a recently recognized ferroptosis facilitator. Axon guidance molecule netrin-1 (Ntn1) functions in neuroprotection against ischemic insult by engaging into its receptor of uncoordinated-5 homolog B (UNC5b) via adenosine 5'-monophosphate-activated protein kinase (AMPK), which potentially binds to BACH1. Whether Ntn1/UNC5b regulates post-stroke ferroptosis through AMPK-BACH1 pathway remains unclear.
View Article and Find Full Text PDFThe derivatives of hirudin-like peptides from the Poecilobdella manillensis exhibit antithrombotic and anti-ischemic stroke effects.
Int J Biol Macromol
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Engineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), State Key Laboratory of Genetic Evolution & Animal Models, Sino-African Joint Research Center, and New Cornerstone Science Laboratory, Kunming Institute of Zoology, the Chinese Academy of Sciences, No.17 Longxin Road, Kunming, Yunnan 650201, China. Electronic address:
Almost all currently approved anticoagulants interfere with hemostasis and increase the risk of bleeding complications. Thus, there is a critical need for safer anti-thrombotic drugs without bleeding risk. Hirudin has demonstrated potent antithrombotic properties, but is clinically limited due to its high bleeding risk.
View Article and Find Full Text PDFDifferences in door-to-device times in a retrospective cohort of patients with ischemic stroke who received CTA only or CTA and CTP imaging.
J Stroke Cerebrovasc Dis
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Providence Brain and Spine Institute, Providence Saint Vincent Medical Center, Portland, OR, USA.
Background: In the treatment of acute ischemic stroke, there are differing views about the utility of computerized tomography perfusion (CTP). Two approaches are employed depending on hospital preference. The first approach is to perform non-contrast computed tomography (CT) scans followed by vascular imaging with computed tomography angiography (CTA) for patients arriving within 6 h of last known well.
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