Background: This study aims to report and evaluate the efficacy of using a novel submental flap for addressing laryngeal stenosis.
Methods: This study involved patients with glottic and supraglottic laryngeal stenosis following horizontal/vertical partial laryngectomy who were refractory to repeated interventions. Kaplan-Meier curves were used to demonstrate the decannulation, and the Mantel-Cox Log-rank test was used to compare the rate difference in quality-of-life subgroup analysis.
Results: The average follow-up time was 30.04 ± 10.60 for all included patients; the flap survival was 100%, with only one patient in the horizontal laryngectomy group reported to have a flap-related complication. The decannulation rate was 93.75% and 80% in the horizontal and vertical groups, respectively, without any statistical analysis (p < 0.05). The average decannulation time was 10.17 ± 5.24 weeks in the horizontal group and 12.25 ± 5.56 in the vertical group.
Conclusion: The modified submental flap technique provides a convenient and effective approach for laryngeal reconstruction in patients with postoperative laryngeal stenosis.
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http://dx.doi.org/10.1002/hed.28125 | DOI Listing |
Rheumatology (Oxford)
March 2025
Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA.
Systemic vasculitis can present with different manifestations, some of which require unique approaches. This session at the 21st International Vasculitis Workshop, examined six studies focused on "Management of Special Situations". In ANCA-associated vasculitis (AAV), two institutions reported on their experience with subglottic stenosis (SGS) from the standpoint of histologic features and management compared to patients with idiopathic SGS.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
January 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, 1a Banacha Str., Warsaw, 02-097 Poland.
Upper airway stenosis is a potentially life-threatening condition that can occur at the level of the larynx, trachea, or multiple sites. It compromises breathing, coughing up secretions or voice production. To date, a wide range of endoscopic and open procedures have been described.
View Article and Find Full Text PDFEBioMedicine
March 2025
Department of Otolaryngology - Head & Neck Surgery, Western University, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Department of Oncology, Western University, London, Ontario, Canada. Electronic address:
Background: The larynx consists of the supraglottis, glottis, and subglottis and each differ in tissue composition, lymphatic drainage, ability to counter infections, and response to injuries. However, the cellular mechanisms driving laryngeal homoeostasis remain largely unexplored. As a result, understanding disease pathogenesis within the larynx including idiopathic subglottic stenosis (iSGS) and intubation-related traumatic stenosis has been challenging.
View Article and Find Full Text PDFEBioMedicine
March 2025
Department of Otolaryngology - Head & Neck Surgery, Western University, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Department of Oncology, Western University, London, Ontario, Canada. Electronic address:
Background: First described in 1972, idiopathic subglottic stenosis (iSGS) is a serious chronic orphan disease characterised by recurrent scarring of the subglottis. Although the cause is unknown, iSGS is almost exclusively restricted to Caucasian females typically in their fourth to sixth decade. However, given its rare incidence (1:400,000), understanding the clinical trajectory and molecular factors associated with iSGS disease development and prognosis has been difficult.
View Article and Find Full Text PDFAnn Surg
March 2025
Department of Thoracic Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Université Paris-Saclay, 133 Avenue de la Résistance, 92350, Le Plessis Robinson, France.
Objective: Our aim was to assess changes in causes, surgical treatments, and outcomes of Acquired non-malignant tracheoesophageal fistula (ANM-TEF) over 40 years of experience.
Background: ANM-TEF are rare but life-threatening disease. Their management are not well established.
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