Quincke's disease is a rare presentation of angioneurotic edema of the uvula alone, likely a Type I immediate hypersensitivity reaction. We raise awareness of this rare but life-threatening case presenting as throat tightness, without rash or facial angioedema, treated with corticosteroids, antihistamines, and β2-agonist nebulization.
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http://dx.doi.org/10.1002/ccr3.70270 | DOI Listing |
Introduction: The pathogenesis of cold urticaria (ColdU) and cold-induced anaphylaxis (ColdA) remains poorly understood, and ColdA is underrepresented in anaphylaxis literature. Laboratory features to guide management are largely unknown. This study evaluated basal serum tryptase (BST) and total immunoglobulin E (IgE) levels in ColdU and ColdA, their associations with clinical features, and the utility of testing for the p.
View Article and Find Full Text PDFFront Allergy
February 2025
Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
World J Clin Pediatr
March 2025
Public Health Directorate, Ministry of Health, Manama 26671, Bahrain.
Background: Although breast milk is ideal for newborns, in some cases, it is replaced with cow's milk, which contains proteins that increase the risk of cow's milk protein allergy (CMPA).
Aim: To evaluate CMPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E (IgE)- and non-IgE-mediated CMPA.
Methods: This retrospective cohort study examined children with CMPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya Medical Complex, Bahrain, between 2014 and 2022, and assessed CMPA prevalence.
Eur J Pharmacol
March 2025
Engineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Sino-African Joint Research Center, and Kunming Institute of Zoology, Chinese Academy of Sciences, No. 17 Longxin Road, Kunming 650201, Yunnan, China. Electronic address:
The contact-kinin system plays a central role in the thromboinflammatory pathology of ischemic stroke. Modulating this pathway represents a promising strategy for the prevention and treatment of ischemic stroke. Based on our recent findings demonstrating that the short peptide SD6 (SLGASD), derived from a specific influenza-related immunoglobulin heavy chain junction region sequence, exhibits anti-coagulant properties, we designed a cyclized version, cycloSD6, and evaluated its anti-ischemic stroke potential.
View Article and Find Full Text PDFJ Allergy Clin Immunol Pract
March 2025
Division of Allergy, Department of Medicine, University of California San Diego, La Jolla, CA; Allergy Section, Medicine Service, San Diego VA Healthcare, San Diego, CA. Electronic address:
Hereditary angioedema with normal C1 inhibitor (HAE-nl-C1INH) was initially described almost a quarter century ago. Considerable progress towards unraveling the mysteries of this complex disease has been made during the intervening years. The ability to diagnose, classify, and treat HAE-nl-C1INH, however, continue to present daunting clinical challenges.
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