Sap beetles (Nitidulidae) are species-rich, highly diverse, widely distributed and exhibit varied food habits. However, studies on nitidulids in Kachin amber are scarce, particularly those involving nitidulids with specialized mandibles. Here, we report a new genus and species of Nitidulidae, gen. et sp. nov., from mid-Cretaceous Kachin amber (approx. 99 Ma). This species is characterized by distinctly enlarged mandibles and a loose three-article antennal club, suggesting it as a stem-group nitidulid. The enlarged mandibles may be a manifestation of sexual dimorphism, as in some extant species. Together with previous studies of fossil nitidulids, our discovery highlights the remarkable diversity and morphological disparity of sap beetles during the late Mesozoic.
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http://dx.doi.org/10.1098/rsos.241761 | DOI Listing |
Oral Maxillofac Surg
March 2025
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Bone defects, particularly in the mandible, pose significant clinical challenges due to the limited regenerative capacity. Effective bone tissue engineering requires biomaterials that promote both osteogenesis and angiogenesis. This study developed an optimized collagen-nano hydroxyapatite scaffold loaded with dexamethasone and stem cells to enhance bone regeneration.
View Article and Find Full Text PDFiScience
March 2025
College of Life and Environmental Sciences, Zhejiang Key Laboratory of Organ Development and Regeneration, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
The specific roles of nonsense-mediated mRNA decay (NMD), a translation-dependent RNA quality control mechanism that degrades mRNAs containing premature termination codons (PTCs), in mammalian craniofacial development have remained unclear. Here, we show that knockout of the essential NMD factor in mouse craniofacial neural crest cells leads to hypoplastic mandibles, subsequently inducing tongue mispositioning and cleft palate formation. Furthermore, loss triggers massive cell apoptosis and disrupts cell differentiation, accompanied by widespread alterations in alternative splicing and a surge in PTC-containing mRNA levels.
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February 2025
Shanghai Jiao Tong University School of Medicine, Institute of Ruijin Hospital, Shanghai, China.
Robotic-assisted dental implantation represents a transformative innovation in modern dentistry, offering enhanced surgical precision and reduced variability. Despite its clinical adoption, the impact of anatomical and bone-related factors on placement accuracy remains underexplored. This retrospective study evaluated 54 implants placed in 30 patients using cone-beam computed tomography (CBCT) and virtual planning software to analyze deviations in crown position, apex position, and angulation.
View Article and Find Full Text PDFExpert Rev Anticancer Ther
March 2025
Department of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Introduction: Oralsquamous cell carcinoma (OSCC) is a significant global health burden. The goals ofneoadjuvant chemotherapy (NACT) are to shrink tumors allowing for moreconservative surgeries, improve survival and potentially improve quality oflife.
Areascovered: Thisreview explores the current evidence of utility of NACT in OSCC management.
Surg Radiol Anat
March 2025
Dental and Oral Medical Center, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Anatomical details regarding venous drainage of the head and neck are an important matter for surgeons to avoid unnecessary complications such as hemorrhage. This report describes a case of the large venous ring around the mandibular condyle found in the cadaver. The left maxillofacial region of a latex-injected embalmed male cadaver (82 years of age at death) was dissected.
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