Schiff bases are an important scaffold for designing drug development. They are characterized by having a carbon-nitrogen double bond. This double bond is synthesized by different synthetic schemes by both the aromatic and aliphatic chains. Bases inspired chemists due to their versatile importance in drug discovery and drug development. A large number of drugs are designed through the heterocyclic Schiff base moieties. This review highlighted the importance of Schiff bases concerning their bioactive importance in drug design. Moreover, amide-iminol tautomerism is a significant tool for the high biological importance of Schiff bases due to the presence of the C=N bond. Furthermore, the reported synthesized heterocyclic scaffolds Schiff bases have a wide range of biological importance. Due to this different biological importance, such as antimicrobial, anticonvulsant, analgesic, antioxidant, antimalarial, anti-inflammatory, anticancer, antidiabetic, and antileishmanial properties, the researcher has shown their interest by synthesizing different heterocyclic Schiff bases. In this review article, biologically active heterocyclic Schiff bases were reviewed intensively concerning drug design and drug development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0113895575320413250126041041 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preparation, Spectral Characterization and Antioxidant Activities of Aminothiophene-Containing Schiff Base and Co(II) and Pd(II) Complexes.
J Biochem Mol Toxicol
March 2025
Department of Medical Services and Techniques, Health Services Vocational School, Mus Alparslan University, Mus, Turkey.
This research focused on synthesizing a Schiff base (L) and its Co(II) and Pd(II) complexes under appropriate conditions to contribute to enhancing antioxidant activity. The ligand was synthesized by reacting methyl 2-amino-4-ethyl-5-methylthiophene-3-carboxylate with 5-bromo-2-hydroxybenzaldehyde. Various analytical techniques were employed to characterize the ligand and its resulting complexes, including microanalysis, H and C NMR spectroscopy, FTIR, electronic spectra, mass spectrometry, magnetic susceptibility, molar conductance, and thermo-gravimetric analysis.
View Article and Find Full Text PDFSynthesis, antibacterial activity, in silico ADMET prediction, docking, and molecular dynamics studies of substituted phenyl and furan ring containing thiazole Schiff base derivatives.
PLoS One
March 2025
Department of Chemistry, Jagannath University, Dhaka , Bangladesh.
This study synthesized eighteen phenyl and furan rings containing thiazole Schiff base derivatives 2(a-r) in five series, and spectral analyses confirmed their structures. The in vitro antibacterial activities of the synthesized analogs against two gram-positive and two gram-negative bacteria were evaluated by disk diffusion technique. Compounds (2d) and (2n) produced prominently high zone of inhibition with 48.
View Article and Find Full Text PDFBismuth(III) complexes of Schiff bases derived from aliphatic amines: interaction with biomolecules and antimicrobial activity.
J Biol Inorg Chem
March 2025
Faculty of Chemistry, Belarusian State University, 4 Independence Avenue, 220030, Minsk, Belarus.
Schiff bases bearing a sterically hindered phenolic moiety and their Bi(III) complexes were synthesized and characterized by physicochemical, quantum chemical, and biological methods. The compounds were screened in vitro against bacterial and yeast strains. It was found that Bi(III) complexes demonstrate higher antimicrobial activity compared to the parent ligands as well as to the commonly used drug (De-Nol®).
View Article and Find Full Text PDFSynthesis, Structure and Photophysical Properties of Dinuclear Zinc(II) Complexes with Schiff Base Bearing p-Phenylenediamine.
J Fluoresc
March 2025
Faculty of Chemistry, Hanoi National University of Education, Hanoi, Vietnam.
Four new dinuclear complexes Zn1-Zn4 were synthesized by the interaction of Zn(NO).4HO with Schiff bases containing p-phenylenediamine. The data of ESI-MS, IR and H NMR spectroscopy showed that the ligands coordinated with Zn(II) via two sets of O, N atoms.
View Article and Find Full Text PDFAZD7648 (DNA-PKcs inhibitor): a two-edged sword for editing genomes.
Funct Integr Genomics
March 2025
National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan.
Clustered regularly interspaced short palindromic repeats (CRISPR-Cas9) has been the most practical technique in genome editing for the last decade. Its molecular mechanism includes steps that occur in a sequence, starting from a break in a double strand to repair. After a double-strand break in the DNA strand, the repairing of DNA done via Homology-Directed Repair (HDR) is considered important in different organisms as it is ideal for precise genome editing and the reduction of unintended mutations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!