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Economic impact of a faricimab vial-sharing protocol in age-related macular degeneration and diabetic macular oedema patients.
Acta Ophthalmol
March 2025
Hospital Sagunto, Ophthalmology Service, Sagunto, Spain.
Desmosome and Hemidesmosome Release via Exosomes from Retinal Pigmented Epithelium - A Precursor to Epithelial-Mesenchymal Transition in Early AMD?
Curr Eye Res
March 2025
McLaughlin Research Institute, Great Falls, MT, USA.
Purpose: This minireview discusses desmosome and hemidesmosome disassembly and/or internalization and subsequent release exosomes in retinal pigmented epithelium (RPE) under oxidative stress conditions, and whether it may be a precursor to epithelial-mesenchymal transition in early Age-related Macular Degeneration (AMD).
Methods: Literature review and discussion of novel findings relevant to the focus of the review.
Results: The RPE forms the outer blood-retinal barrier, and like other epithelia it has several different types of cell-cell junctions, such as desmosomes.
Associations of fundus tessellation, myopic diffuse chorioretinal atrophy and choroidal thickness with visual acuity in myopia.
Acta Ophthalmol
March 2025
Beijing Visual Science and Translational Eye Research Institute (BERI), Eye Center of Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China.
Purpose: To explore associations between stages of myopic macular degeneration (MMD) and visual acuity and influencing parameters.
Methods: Participants of the population-based study Beijing Eye Study (n = 3468 participants) underwent a detailed ocular and systemic examination.
Results: Assessable images were available for 3040 (87.
Silicone Oil Droplets in the Vitreous After an Anti-vascular Endothelial Growth Factor (VEGF) Injection: A Complication of Syringe Lubrication.
Cureus
February 2025
Ophthalmology, Dr. Suresh Babu Eye Foundation, Kasaragod, IND.
Intravitreal anti-vascular endothelial growth factor (VEGF) injections are a cornerstone treatment for various retinal conditions, including diabetic macular edema and age-related macular degeneration. While generally safe, these injections can introduce unintended substances, such as silicone oil droplets, into the vitreous cavity due to the silicone-based lubricant used in syringe manufacturing. Although frequently asymptomatic, silicone oil droplets can occasionally cause significant visual disturbances and discomfort.
View Article and Find Full Text PDFAtrial Fibrillation as a Predictor of Age-Related Macular Degeneration.
J Cardiovasc Electrophysiol
March 2025
Intermountain Medical Center Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA.
Background: Aging of the population has resulted in more patients living with atrial fibrillation (AF) and age-related macular degeneration (AMD). AF is associated with macro- and micro-thromboembolism, microvascular dysfunction, and system inflammation. Organ systems sensitive to the long-term systemic and vascular disease associations of AF will likely develop dysfunction over time.
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