Background: This study aims to evaluate the clinical application of Denonvilliers' fascia arch (DFA) as a novel anatomical landmark in laparoscopic radical prostatectomy (LRP), comparing with the conventional extraperitoneal LRP approach.

Patients And Methods: This retrospective cohort study analyzed 304 patients who underwent LRP between January 2019 and January 2024. Patients were divided into two groups: the experimental group (n = 152), who underwent extraperitoneal LRP using DFA as a landmark, and the control group (n = 152), who underwent conventional LRP. Perioperative outcomes, including surgical time, blood loss, complications, and functional recovery (urinary continence and erectile function), were evaluated. Logistic regression analysis assessed the risk factors for postoperative urinary incontinence and erectile dysfunction.

Results: The experimental group showed significantly improved outcomes. The median surgical time was 134 minutes, compared with 171 minutes in the control group (P < 0.001). Intraoperative blood loss was lower in the experimental group (58 mL vs. 103 mL, P < 0.001). The incidence of rectal injury was lower (1 vs. 9 cases, P = 0.010), and the Clavien-Dindo grade ≥ II complication rate was significantly reduced (3.3% vs. 10.4%, P = 0.013). The experimental group also showed better recovery in urinary continence (30.9% vs. 17.8%, P = 0.008) and erectile function (median IIEF score of 8 vs. 6, P < 0.001).

Conclusions: The use of DFA as a landmark in LRP improves surgical efficiency, reduces complications, and enhances functional recovery compared to the conventional approach. DFA provides an effective method for precise DF identification, offering substantial clinical value in LRP.

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-025-17086-2DOI Listing

Publication Analysis

Top Keywords

experimental group
16
application denonvilliers'
8
denonvilliers' fascia
8
fascia arch
8
anatomical landmark
8
landmark laparoscopic
8
laparoscopic radical
8
radical prostatectomy
8
retrospective cohort
8
cohort study
8

Similar Publications

Insight into the Specific Adsorption of Cu(II) by a Zinc-Based Metal-Organic Framework Mediated via a Proton-Exchange Mechanism.

Langmuir

March 2025

China Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, School of Chemistry and Chemical Engineering, School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China.

In the context of scarce metal resources, the one-step separation and recovery of high-value copper metal ions from secondary resources is of significant importance and presents substantial challenges. This study identified a Zn-based triazole MOF (Zn(tr)(OAc)) with accessible and noncoordinated terminal hydroxyl groups within its framework. The Zn(tr)(OAc) surpasses most currently reported Cu-specific MOF adsorbents regarding adsorption capacity and Cu selectivity.

View Article and Find Full Text PDF

Aim And Objectives: In the preoperative period, non-pharmacological methods such as multimedia applications and visual and audio technological tools are used to reduce children's fear and anxiety levels and to distract their attention to create a more enjoyable experience. One of these innovative technologies having attracted attention recently is augmented reality technology. The study was aimed investigating the effects of reading an augmented reality storybook on fear and anxiety levels of children in the age group of 7-12 years in the preoperative period.

View Article and Find Full Text PDF

Background: Ambient Mass Spectrometry (AMS) encompasses a group of techniques that have emerged as powerful strategies for direct, in-situ and high-throughput analysis, also in compliance with the principles of green analytical chemistry. Swab Touch Spray-Mass Spectrometry (Swab TS-MS) is a home-made AMS technique that involves the use of a medical swab as sampling tool and electrospray probe. To date, Swab TS-MS has been applied only for the analysis of small molecules, especially in forensic and medical fields, leaving the analysis of peptides and proteins still unexplored.

View Article and Find Full Text PDF

Identifying promising peptide targets for leprosy serological tests: From prediction to ELISA.

J Genet Eng Biotechnol

March 2025

Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Programa de Pós-Graduação em Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Leprosy remains a significant health concern, particularly in India, Brazil, and Indonesia. Early diagnosis is essential to prevent complications, highlighting the need for improved diagnostic tools. This study aimed to identify novel Mycobacterium leprae antigens and assess their effectiveness against human sera through immunotools for antibody response evaluation.

View Article and Find Full Text PDF

Thymus satureioides is an endemic and medicinal plant of Morocco, widely distributed in the arid and semiarid habitats. Communally used in traditional medicine. In the current study, twelve Inter-Simple Sequence Repeats (ISSR) primers combined with 11 agro-morphological traits were applied to evaluate 60 accessions of T.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!