Skin and subcutaneous diseases represent a significant public health burden, profoundly impacting quality of life, social interactions, mental health, and daily activities-raising concerns worldwide. In modern cryogenics, cryosurgery is among the therapeutic approaches employed by healthcare professionals to address this broad and complex range of diseases. Over the past four decades, cryosurgery has evolved into a valuable treatment option, used alone or as an adjunct therapy, and is adaptable to the needs of various special populations. This approach offers distinct advantages over established treatments due to its safety, efficiency, feasibility, and cost-effectiveness. However, a comprehensive, up-to-date review of cryosurgery's applications is lacking, which limits research dissemination and recognition among dermatologists. This review aims to provide an overview of cryosurgery principles and its current clinical practice in dermatology, covering a broad range of benign, premalignant, and malignant cutaneous conditions, and highlighting its potential as an essential approach in global healthcare.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884497 | PMC |
| http://dx.doi.org/10.21873/invivo.13865 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Do The Inflammatory Cells In The Blood And Tissues Have Predictive And Prognostic Value In Benign, Premalignant And Malignant Lesions Of The Larynx?
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Pathology, Health Science University, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Objective: The aim of our study is to investigate the predictive and prognostic value of inflammatory cells in blood and tissues in laryngeal lesions.
Methods: The data of a total of 112 patients, of whom 36 had benign, 38 had premalignant and 38 had malignant laryngeal lesions, were analyzed retrospectively. Along with the demographic characteristics of the patients, hemogram parameters were also captured by hematoxylin-eosin staining performed on pathology preparation lymphocytes and neutrophils, and Langerhans cells count was carried out by immunohistochemical staining.
C5aR1 Promotes Invasion, Metastasis and Poor Prognosis in Cutaneous Squamous Cell Carcinoma.
Am J Pathol
March 2025
From the Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland; FICAN West Cancer Research Laboratory, University of Turku and Turku University Hospital, Turku, Finland. Electronic address:
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and the metastatic disease is associated with poor prognosis. Here, the role of complement C5a receptor, C5aR1, was examined in the progression and metastasis of cSCC. C5aR1 expression was increased in cSCC cells in 3D spheroid co-culture model in the presence of fibroblasts, and treatment with recombinant C5a enhanced the invasion of cSCC cells.
View Article and Find Full Text PDFResection or bypass surgery for benign or malignant esophageal pathologies presents multiple challenges, which is why it is addressed to centers of digestiveexcellence. One such challenge is the restoration of the continuity of the digestive tract, the colon being an important option for esophageal substitution. Lon-term follow up of patients with colon reconstruction is essentially related to digestive-nutritional problems.
View Article and Find Full Text PDFAutomated cancer diagnosis research often focuses on a binary task - recognize dysplasia and cancer from other lesions. However, other clinical conditions have estimated malignant transformation rates. Grouping these oral potentially malignant diseases with benign conditions may not be ideal.
View Article and Find Full Text PDFPRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation.
Lab Invest
February 2025
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston MA 02115.
Preferentially Expressed Antigen in Melanoma (PRAME) and Ten-Eleven Translocation (TET) dioxygenase-mediated 5-hydroxymethylcytosine (5hmC) are emerging melanoma biomarkers. We observed an inverse correlation between PRAME expression and 5hmC levels in benign nevi, melanoma in situ, primary invasive melanoma, and metastatic melanomas via immunohistochemistry and multiplex immunofluorescence: nevi exhibited high 5hmC and low PRAME, whereas melanomas showed the opposite pattern. Single-cell multiplex imaging of melanoma precursors revealed that diminished 5hmC coincides with PRAME upregulation in premalignant cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!