We report on sensor platform including both the advanced nanostructured Prussian Blue based hydrogen peroxide sensor and the cooling-free breath aerosol (BA) condenser. The latter provides an order of magnitude more concentrated BA samples as compared to breath condensate collected traditionally through cooling; the conclusion is based on both: specimen's conductivity, the generally accepted dilution marker, and the evaluated HO levels (2.2-3.2 μM for healthy subjects). Reliable detection of submicromolar HO content is possible with the sensor based on nanostructured Prussian Blue (0.45-0.70 nmol cm) stabilized with nickel hexacyanoferrate (1.0-1.3 nmol cm). A possibility to discover the noninvasively accessed marker for post-COVID-19 syndrome illustrates the horizons of the platform in clinical diagnostics.
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| http://dx.doi.org/10.1016/j.talanta.2025.127792 | DOI Listing |
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