This article describes a new multifunctional oral cavity simulator (MOCS) that allows, with little technical support and easy handling, the laboratory development of dental hard tissue lesions under clinically similar conditions. The MOCS consists of a heating unit containing three independent cylindrical chambers with three specimen holders inside. Liquids flow through the surfaces of specimens by inlets on the lid of the chamber, which is connected to a medium/artificial saliva source through a computer-controlled peristaltic pump. The design, operational principles, and clinical application of this simulator, such as microcosm-induced development of carious-like lesions, acidic-induced erosion-abrasion like-lesions, and testing the anticariogenic effect of restorative materials, are shown. The MOCS can mimic several aspects of the oral cavity, being a promising device for assessing dental hard tissue lesions.
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http://dx.doi.org/10.1590/1807-3107bor-2025.vol39.022 | DOI Listing |
Sci Adv
March 2025
Department for Integrative Evolutionary Biology, Max Planck Institute for Biology Tübingen, Max-Planck Ring 9, Tübingen, 72076, Germany.
Environmental influences on traits and associated transgenerational epigenetic inheritance have widespread implications but remain controversial and underlying mechanisms poorly understood. We introduce long-term environmental induction experiments on alternative diets in , a nematode exhibiting mouth-form plasticity including predation, by propagating 110 isogenic lines for 101 generations with associated food-reversal experiments. We found dietary induction and subsequent transgenerational inheritance of the predatory morph and identified a role of ubiquitin ligase EBAX-1/ZSWIM8 in this process.
View Article and Find Full Text PDFRev Bras Enferm
March 2025
Universidade Estadual de Londrina. Londrina, Paraná, Brazil.
Objectives: to assess prevalence, intensity, discomfort, defining characteristics of thirst and signs of oral mucosa hydration in Intensive Care Unit patients.
Methods: quantitative and analytical study, carried out in a tertiary hospital in six of the seven Intensive Care Units, with a sample of 60 patients. Variables related to thirst were analyzed according to their nature.
J Cancer Educ
March 2025
Département d´Odontologie, Faculté de Santé, Service d´Odontologie, Centre HospitalierUniversitaire, Université de Toulouse, 3 chemin des Maraîchers, Toulouse, 31400, France.
A patient who had undergone radiation therapy for cancer developed a white coating on their tongue. This was initially misdiagnosed as a fungal infection, leading to unnecessary treatment. The actual cause was dry mouth, a common side effect of radiation therapy.
View Article and Find Full Text PDFClin Oral Investig
March 2025
Department of Preventive and Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University (UNESP), Araçatuba, SP, Brazil.
Objectives: This systematic review and meta-analysis (SRM) evaluated the effect of incorporating calcium-based bioactive agents in bleaching gels on dental structure preservation and whitening efficacy.
Methods: A comprehensive search was conducted across databases up to November 2024. Two independent reviewers screened and selected clinical trials and in vitro studies evaluating the effects of calcium-based bioactive agents in bleaching gels, following predefined PICO criteria.
Dent Med Probl
March 2025
Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Background: Chlorhexidine digluconate (CHG) is considered the most effective and safe antimicrobial agent in dentistry. Recently, it has often been produced in the form of preparations with additional substances that may modify its effect.
Objectives: The aim of the present study was to compare the efficacy of various simple and combined CHG rinses against selected bacterial and yeast strains.
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