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Temporal Dynamics of Depressive Symptoms, Apathy, Daily Activities, and Cognitive Decline in Older People From the General Population: A Network Analysis.
Am J Geriatr Psychiatry
February 2025
Department of Psychiatry (AJCS, EJG), Leiden University Medical Center, Leiden, The Netherlands; Health Campus The Hague (EJG), Department of Public Health & Primary Care, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
Background: The prevalence of depressive symptoms, apathy, and cognitive decline increases with age. Understanding the temporal dynamics of these symptoms could provide valuable insights into the early stages of cognitive decline, allowing for more timely and effective treatment and management.
Methods: Participants from the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial cohort with baseline and ≥3 follow-up measurements were included, with a median of 7.
OMEGA-guided DNA polymerases enable random mutagenesis in a tunable window.
Trends Biotechnol
March 2025
Tidetron Bioworks Technology (Guangzhou) Co., Ltd, Guangzhou Qianxiang Bioworks Co., Ltd, Guangzhou, Guangdong 510000, PR China. Electronic address:
Targeted random mutagenesis is crucial for breeding, directed evolution, and gene function studies, yet efficient tools remain scarce. Here, we present obligate mobile element guided activity (OMEGA)-R, an innovative targeted random mutagenesis system that integrates SpyCatcher-enIscB and PolI3M-TBD-SpyTag, outperforming existing state-of-the-art technologies in key metrics, such as protein size, mutagenesis efficiency, window length, and continuity. OMEGA-R achieves a dramatic enhancement of on-target mutagenesis, reaching a rate of 1.
View Article and Find Full Text PDFEffectiveness of COVID-19 vaccines against laboratory-confirmed SARS-CoV-2 infection amongst health workers, Windhoek, Namibia.
Vaccine
March 2025
Robert Koch Institute, Am Nordufer 20, 13353 Berlin, Germany. Electronic address:
Introduction: As of 24 October 2021, 128,868 laboratory-confirmed COVID-19 cases and 3550 deaths were reported from Namibia. The national COVID-19 vaccination campaign that started in March 2021 included health workers (HWs) as a priority group. The vaccines most administered were Sinopharm, AstraZeneca, Pfizer-BioNtech, and Janssen.
View Article and Find Full Text PDFAnalysis of Femoral Flexion Angle Distribution and Range of Motion in Total Knee Arthroplasty.
J Arthroplasty
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Department of Orthopaedic Surgery, Northwell Orthopaedic Institute, Lenox Hill Hospital, New York, New York.
Background: Optimal coronal and rotational alignment in total knee arthroplasty is essential for satisfactory outcomes. There has been limited focus on sagittal alignment in assessing outcomes. This study investigated the impact of femoral implant flexion (FF) angle on knee kinematics and postoperative outcomes.
View Article and Find Full Text PDFUnderstanding Electron Beam-Induced Chemical Polymerization Processes of Small Organic Molecules Using Operando Liquid-Phase Transmission Electron Microscopy.
ACS Nano
March 2025
Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Korea.
Electron beams evolved as important tools for modern technologies that construct and analyze nanoscale architectures. While electron-matter interactions at atomic and macro scales are well-studied, a knowledge gap persists at the molecular to nano level─the scale most relevant to the latest technologies. Here, we employ liquid-phase transmission electron microscopy supported by density functional theory calculations and a mathematical random search algorithm to rationalize and quantify electron beam-induced processes at the molecular level.
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