The current study aims to describe the macroscopic, histological and histochemical features of the digestive tract of omnivorous fish species Panga Pangasius hypophthalmus-which derives from Southeast Asian watersheds-with emphasis on secretory cell types and their histochemical reactions. Results have evidenced that the anatomical organisation of the digestive tract in the coelomic cavity of the investigated species is similar to that of other omnivorous teleosts, except for a pneumatic duct linking the distal portion of their oesophagus to their swim bladder. It is worth highlighting that both the oesophagus and the stomach have well-developed histological layers and that the stomach has a saccular shape and is highly distensible to ensure longer food storage time. Intestinal loops are convoluted and present well-developed mucosal folds with varying widths, heights and thicknesses; these features increase the nutrient absorption surface. The digestive tract presented histological and histochemical features similar to those of other siluriform fish that show the same feeding habits and secretory cells throughout the digestive tract, whose acid and neutral secretions guarantee the functionality of digestive processes.
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http://dx.doi.org/10.1111/ahe.70026 | DOI Listing |
Small Methods
March 2025
School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, 201203, P. R. China.
Elucidating in vivo lipolysis is crucial for clarifying the underlying mechanisms and in vivo fates of lipid-based nanocarriers, which are essential oral drug delivery carriers. Current mainstream methodologies use various in vitro digestion models to predict the in vivo performance of lipid formulations; however, their accuracy is often impeded by the complicated environment of the gastrointestinal tract. Although fluorescence labeling with conventional probes partly reveals the in vivo translocation of lipid nanocarriers, it fails to elucidate the lipolysis process because of poor signal discrimination among nanocarriers, free probes, and mixed micelles (lipolysis end-products).
View Article and Find Full Text PDFFront Immunol
March 2025
Department of Immuno-Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
In recent years, the rapid progress in oncology, immunology, and molecular biology has dramatically advanced cancer immunotherapy, particularly CAR-T cell therapy. This innovative approach involves engineering a patient's T cells to express receptors that specifically target tumor antigens, enhancing their ability to identify and eliminate cancer cells. However, the effectiveness of CAR-T therapy in solid tumors is often hampered by the challenging tumor microenvironment (TME).
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
January 2025
Department of ENT and HNS, Bangalore Medical College and Research Institute, Bangalore, Karnataka India.
Unlabelled: The retropharyngeal space is a distinct space along the midline that extends from the skull base to the upper mediastinum. Retropharyngeal space lesions can produce significant morbidity, given their proximity to the aero-digestive tract, skull base and its ability to extend into upper mediastinum. Difficulty in assessing the retropharyngeal space by direct inspection or physical examination may cause delay in diagnosis and early intervention thus knowledge about these lesions and their effective management is essential.
View Article and Find Full Text PDFGastroenterol Rep (Oxf)
March 2025
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, Hunan, P. R. China.
Exocrine pancreatic insufficiency (EPI) is a major cause of maldigestion and malnutrition, resulting from primary pancreatic diseases or other conditions. As the prevalence of EPI continues to rise, accurate identification of its etiology has become critical for the diagnosis and treatment of pancreatic secretory insufficiency. EPI can result from both pancreatic and non-pancreatic disorders.
View Article and Find Full Text PDFFront Microbiol
February 2025
Department of Pharmacy, Mie University Hospital, Mie, Japan.
Introduction: Isavuconazole, a broad-spectrum triazole approved by the United States Food and Drug Administration (FDA) in 2015, moderately inhibits cytochrome P450 3A4. Although antifungal agents are often used concomitantly with cyclosporine, the effect of switching from voriconazole to isavuconazole on the blood cyclosporine level remains unclear.
Case: A 63-year-old Japanese male was administered oral cyclosporine (10:00 and 21:00) for severe aplastic anemia.
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