Solutions to healthcare's most persistent and pervasive challenges remain elusive because we approach them as navigating oppositional tensions: the need to drive efficiency versus improve quality, to leverage cutting-edge technology versus maintain human compassion, to address population health versus providing care to the patient in front of you. The key to transforming healthcare lies in the ability of healthcare leaders to recognize when oppositional tensions are in fact paradoxes at play, to increase the capability and collective capacity to navigate them. Paradox science contends sustainable solutions to intractable challenges come not from eliminating the tensions that operate within the complexity but from the ability of those involved to hold opposing ideas in productive balance. It empowers leaders and their teams to find innovative paths by engaging with tensions directly. This perspective piece outlines three steps healthcare leaders can take to apply paradox science in practice, providing descriptions and example actions for each: 1) Clarify the paradox, 2) Encourage experimentation, and 3) Adopt a dynamic view. Moving forward, health leaders must leverage paradox science to drive forward innovation agendas in order to truly transform the healthcare experience for patients, populations, and the health workforce that serves them.
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http://dx.doi.org/10.2147/JHL.S512053 | DOI Listing |
Echocardiography
March 2025
Department of Physical Therapy, Faculty of Health Science, Kyorin University, Mitaka City, Tokyo, Japan.
Purpose: Central hypovolemia is considered to lead to a compensatory increase in cardiac contractility. From a physiological perspective, left ventricular (LV) twisting motion, which plays an important role in maintaining cardiac output, should be enhanced during central hypovolemia, but previous studies have shown inconsistent findings. Using 3D echocardiography, we tested the hypothesis that the LV twisting and untwisting motion would be enhanced during severe central hypovolemia.
View Article and Find Full Text PDFClin Rev Allergy Immunol
March 2025
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Uveitis involves a complex interplay of immune cell infiltration and cytokine imbalances, with Th17 cells playing a central role in this process. Th17 cells contribute to disease pathogenesis by promoting inflammation, recruiting additional immune cells, and directly damaging retinal tissues. This review discusses the current knowledge on therapeutic strategies targeting Th17-related cytokines, including cytokine blockade, small molecule inhibitors, and immunomodulatory approaches.
View Article and Find Full Text PDFEval Rev
March 2025
Graduate School of Education, Stanford University, Stanford, CA, USA.
The recognition that researcher discretion coupled with unconscious biases and motivated reasoning sometimes leads to false findings ("p-hacking") led to the broad embrace of study preregistration and other open-science practices in experimental research. Paradoxically, the preregistration of quasi-experimental studies remains uncommon although such studies involve far more discretionary decisions and are the most prevalent approach to making causal claims in the social sciences. I discuss several forms of recent empirical evidence indicating that questionable research practices contribute to the comparative unreliability of quasi-experimental research and advocate for adopting the preregistration of such studies.
View Article and Find Full Text PDFAngiology
March 2025
Department of Cardiology, Thoraxcentrum, Erasmus MC, Rotterdam, Holland.
BMC Public Health
March 2025
Escuela de Gobierno Alberto Lleras Camargo, Universidad de los Andes, Bogotá, Colombia.
Background: The global rise in dementia prevalence poses a significant public health challenge, particularly in low- and middle-income countries where resources for diagnosis, treatment, and support are constrained. Addressing this issue, the World Health Organization's 2017-2025 global action plan on dementia envisions a future where dementia is preventable, and individuals with dementia and their caregivers receive dignified support.
Methods: Using a qualitative research design, this study explores stakeholder perspectives on dementia in Colombia, framed by the World Health Organization's global action plan.
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