The concept of posterior cruciate ligament (PCL)-substituting total knee prostheses has been widely used for total knee arthroplasty (TKA). This design provides better femoral rollback with knee flexion, as it permits more stability under flexion by preventing tibial posterior subluxation. Here, we report a case of an unusual presentation of polyethylene tibial post fracture in a polio patient. Our patient had a history of staged bilateral TKA five years prior to the new presentation. Once the diagnosis was confirmed, the patient was admitted electively for TKA revision and polyethylene exchange. The procedure went well and without complications, and the patient was satisfied upon follow-ups in the clinic.
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http://dx.doi.org/10.1093/jscr/rjaf084 | DOI Listing |
Front Pediatr
February 2025
Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rosai-Dorfman disease (RDD) is an unusual, non-malignant proliferative disorder involving non-Langerhans cell histiocytes, characterized by a wide range of clinical presentations and distinctive atypical morphological patterns. The concurrent manifestation of acute lymphoblastic leukemia (ALL) alongside RDD is exceptionally rare. Here, we present the case of a 14-year-old male patient diagnosed with ALL who, during the consolidation phase of chemotherapy, developed multifocal bone, dural, and liver lesions, as confirmed through CT and MRI imaging.
View Article and Find Full Text PDFChem Sci
March 2025
Department of Chemistry, Indian Institute of Technology Kanpur Kanpur - 208016 India
Kadcotriones and kadcoccitanes, renowned for their intricate 6/6/5-tricyclic and 6/6/5/6-tetracyclic ring systems, respectively, exhibit promising biological activities. This work proposes a biosynthetic pathway that elucidates how nature synthesizes these triterpenoids from lanosterol. Inspired by this pathway, we present the first biomimetic syntheses of kadcoccitane H and kadcotrione C methyl ester.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
March 2025
Hospices Civils de Lyon, Hôpital Femme Mère Enfant, Service d'Endocrinologie Pédiatrique et Pédiatrie Générale, Bron, France.
Introduction: McCune-Albright syndrome (MAS) is a rare disease caused by somatic gain-of-function variants in the gene that lead to constitutive activation of the G protein alpha subunit (Gsα). Pathologic consequences can involve several tissues. Fibrous dysplasia (FD), café-au-lait skin macules and hyperfunctioning endocrinopathies are classic manifestations.
View Article and Find Full Text PDFAdenoid cystic carcinoma (ACC) is a relatively uncommon tumor among head and neck cancers, with laryngeal involvement, typically subglottic, being exceptionally rare. While ACC usually originates in the salivary glands, its occurrence in the larynx is highly unusual. Laryngeal adenoid cystic carcinoma (LACC) is characterized by indolent growth, frequent perineural invasion, and a tendency for local recurrence.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
March 2025
Florida International University Herbert Wertheim College of Medicine, Miami, Florida, USA.
Spontaneous coronary artery dissection (SCAD) is a relatively rare and underdiagnosed condition that can lead to acute coronary syndrome (ACS), with a notable incidence in young female patients without traditional cardiovascular risk factors. We present an unusual case of SCAD in a young male patient in the absence of common predisposing factors such as fibromuscular dysplasia (FMD), connective tissue disorders, and systemic inflammatory conditions. A 29-year-old man presenting with chest pain was diagnosed with SCAD involving the left anterior descending artery (LAD), resulting in an acute myocardial infarction (MI).
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