Arboviruses pose significant public health challenges globally, particularly in Pakistan, where deforestation, climate change, urbanization, inadequate sanitation, and natural disasters have all contributed to the spread of mosquito-borne flavivirus diseases like dengue fever. The lack of a thorough national surveillance system has made it difficult to determine the extent and distribution of these diseases. Concern has been raised by recent outbreaks of West Nile virus (WNV) and chikungunya (CHIKV) epidemics, which may lead to Zika virus (ZIKV) outbreaks in the future. Additionally, hospital-based surveillance has detected the Japanese encephalitis virus (JEV) in the region. Evidence also points to the presence of additional arboviruses in healthy populations, such as the Karshi virus (KSV), Tamdy virus (TAMV), Crimean-Congo hemorrhagic fever virus (CCHFV), and severe fever with thrombocytopenia syndrome virus (SFTSV). This review aims to address the risk factors linked to these diseases, provide specific policy recommendations for efficient disease prevention and control, and describe the epidemiological trends of these diseases in Pakistan while emphasizing the critical need for improved surveillance and thorough epidemiological investigations.
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http://dx.doi.org/10.3390/v17020232 | DOI Listing |
Plant Dis
March 2025
College of science, King Saud University, Department of Botany and Microbiology, Riyadh, Riyadh, Saudi Arabia;
Banana (Musa spp.) is widely cultivated as the major fruit in Pakistan. Anthracnose fruit rot caused by various Colletotrichum spp.
View Article and Find Full Text PDFBMJ Open
March 2025
National Institute of Cardiovascular Diseases, Karachi, Pakistan.
Objectives: Accurately predicting short-term MACE (major adverse cardiac events) following primary percutaneous coronary intervention (PCI) remains a clinical challenge. This study aims to assess the effectiveness of four established risk scores in predicting short-term MACE after primary PCI.
Design: Prospective observational study.
Microb Pathog
March 2025
Department of Physics, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia. Electronic address:
This study aims to isolate and identify both diseased and healthy fish pathogens of Ctenopharyngodon idella, Labeo rohita and Oreochromis niloticus and assess their antibacterial and biofilm supressing activities against fish pathogens. It explores their potential to inhibit and degrade biofilms, serving as an alternative to antibiotics in aquaculture while enhancing fish health and disease resistance. Furthermore, the research endeavors to assess the biofilm degradation potential of antibiotics and probiotics, both individually and in combination.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Basis Dis
March 2025
Karachi Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Karachi, Sindh, Pakistan. Electronic address:
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by inflammatory synovial tissue, joint deterioration, and effects on systems other than the joints. The biological process underlying the progression of the disease remains unknown, however cell-mediated immunity plays an important part in the onset of RA. The current study investigated the involvement of the JAK-STAT pathway genes (JAK-1, IL-6, and SOCS-2) in the pathogenesis of RA (Rheumatoid arthritis).
View Article and Find Full Text PDFPathol Res Pract
March 2025
Biochemistry Dept., Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt. Electronic address:
Background: The infiltration of lateral lymph nodes (LLN) plays a crucial role in the staging and treatment of individuals with locally advanced rectal cancer (LARC). This meta-analysis aimed to compare the efficacy of extended mesorectal excision (eTME) versus traditional mesorectal excision (TME-alone) in patients with clinically enlarged (LLN) concomitant neoadjuvant chemoradiation.
Methods: This study is registered with PROSPERO (CRD42023457805).
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