Advances in medical nanobiotechnology have notably enhanced the application of snake venom toxins, facilitating the development of new therapies with animal-derived toxins. The vast diversity of snake species and their venom complexities underline the need for ongoing research. This review is dedicated to exploring the integration of snake venom with nanoparticles to enable their use in human therapies aiming to develop treatments. The complex mixture of snake venom not only inflicts significant pathological effects but also offers valuable insights for the creation of innovative therapies, particularly in the realm of nanobiotechnology. Nanoscale encapsulation not only mitigates the inherent toxicity of snake venom but also amplifies their antitumoral, antimicrobial, and immunomodulatory properties. The synergy between venom-derived macromolecules and nanotechnology offers a novel pathway for augmenting the efficacy and safety of conventional antivenom therapies, extending their applicability beyond treating bites to potentially addressing a myriad of health issues. In conclusion, nanotechnology presents a compelling therapeutic frontier that promises to improve current treatment modalities and ameliorate the adverse effects associated with venomous snakebites.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11858983 | PMC |
http://dx.doi.org/10.3390/pharmaceutics17020204 | DOI Listing |
Background: Snake bites are a major cause of emergency visits in tropical countries like India, with actual mortality and morbidity likely higher due to underreporting. The aim of the study was to analyze the clinical and demographic profiles of snake bites at the Department of Emergency Medicine, AIIMS Rishikesh, over two years (July 2021 to July 2023).
Methods: Patients aged over 18 with witnessed or suspected snake bites were included.
Objectives: To investigate the frequency, timing, and characteristics of cardiovascular collapse after snakebite in Australia, and the complications of collapse following envenoming.
Study Design: Observational study; analysis of prospectively collected demographic and clinical data.
Setting, Participants: People with confirmed snake envenoming recruited to the Australian Snakebite Project at one of 200 participating Australian hospitals, 1 July 2005 - 30 June 2020.
Background: Some North American rattlesnake venoms and angiotensin converting enzyme inhibitor (ACEI) medications each increase bradykinin levels in humans, with clinical effects attributable to bradykinin described in exposed populations. Influence of ACEI exposure on persons with snake envenomation has not been studied. We used data from the ACMT North American Snakebite Registry (NASBR) to determine if use of ACEI medications at the time of rattlesnake envenomation is associated with increased rate of systemic toxicity.
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March 2025
Department of Emergency, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, 530201, Guangxi, China. Electronic address:
Purpose: This study aimed to investigate the biometric characterization of pathogenic microorganisms associated with bloodstream infections in patients bitten by venomous snakes, and to determine whether the composition of these microorganisms influences the effects of snake venom.
Methods: The composition and relative abundance of microorganisms were statistically analyzed using metagenomic next-generation sequencing (mNGS) on blood samples from patients with varying degrees of snakebite injuries. These patients were admitted to the our study.
J Taibah Univ Med Sci
February 2025
Dow College of Biotechnology, Dow University of Health Sciences, Karachi, Pakistan.
Objective: This study assessed the inhibitory potential of proteins extracted from seeds on snake venom toxic enzymes along with their potential antioxidant and antibacterial activities.
Methods: Crude proteins were extracted using common biological buffers (20 mM acetate, 20 mM phosphate and 20 mM Tris) at a ratio of 1:5 followed by 80 % ammonium sulfate precipitation, dialysis, and lyophilization. Then the lyophilized extracts were resolved on 15 % sodium dodecyl sulfate polyacrylamide electrophoresis (SDS-PAGE) gels.
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