This study explores the potential of the mushroom fermentation supernatant (FS-PEWS) as an intervention for mitigating sodium deoxycholate (SDC)-induced intestinal barrier dysfunction and inflammation. : FS-PEWS was assessed for its protective effects against SDC-induced barrier dysfunction and inflammation using an Caco-2 cell model and colonic biopsies from healthy adult donors, where barrier integrity, permeability, immunomodulation and receptor-mediated pathways were evaluated. In Caco-2 cells, SDC exposure downregulated , , and expression, with FS-PEWS restoring and levels while maintaining cell viability. In colonic biopsies from healthy adults, FS-PEWS maintained tissue integrity and selectively mitigated transcellular permeability without affecting paracellular permeability when combined with the stressor. Additionally, FS-PEWS exhibited potent anti-inflammatory effects, reducing pro-inflammatory cytokines, e.g., , , and and modulating receptor-mediated pathways, i.e., , . These results demonstrate the potential of FS-PEWS to sustain intestinal barrier function and modulate immune responses under stress, highlighting its therapeutic potential for managing gut barrier dysfunction and inflammation associated with microbial metabolite-induced disruptions.
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| http://dx.doi.org/10.3390/nu17040694 | DOI Listing |
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