This research paper presents the findings of a design optimization analysis conducted on additive-manufactured thermoplastic sandwich structures with hexagonal honeycombs subjected to quasi-static three-point bending. Based on experimental results, finite element analysis, and analytical models, the relationship between four selected design variables (i.e., cell wall length ratio, cell wall angle, cell wall thickness, and skin thickness) and the structure's mass, flexural stiffness, and maximum load capacity was determined. The influence of each design variable on the aforementioned structural properties was mathematically represented using three scaling laws to formulate a multi-objective optimization problem. Two conflicting objective functions, one for the mass and the other for the reciprocal of the maximum load capacity, along with a nonlinear constraint equation for the minimum allowed flexural stiffness of the sandwich structure were developed. The optimal values of the design variables were determined using two optimization methods, the Pareto optimal front and genetic algorithm, and by applying the Improved Minimum Distance Selection Method (IMDSM). Optimized designs were obtained for different values of flexural stiffness. It was found that, independently of the stiffness constraint value, the optimal value of the cell wall length ratio was 0.2 and the optimal cell wall thickness was 1.4 mm, which correspond to the minimum cell wall length ratio and maximum cell wall thickness considered in this study, respectively. On the other hand, if higher flexural stiffness is required for the structure, both cell wall angle and skin thickness must be increased accordingly. Furthermore, an increase in flexural stiffness is accompanied by an increase in both the mass and maximum load capacity of the structure.
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http://dx.doi.org/10.3390/ma18040867 | DOI Listing |
Sci Transl Med
March 2025
Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Postoperative abdominal adhesions are the leading cause of bowel obstruction and a cause of chronic pain and infertility. Adhesion formation occurs after 50 to 90% of abdominal operations and has no proven preventative or treatment strategy. Abdominal adhesions derive primarily from the visceral peritoneum and are composed of polyclonally proliferating tissue-resident fibroblasts.
View Article and Find Full Text PDFSci Adv
March 2025
Center for Infectious Biology, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Invasive infections by encapsulated bacteria are the major cause of human morbidity and mortality. The liver resident macrophages, Kupffer cells, form the hepatic firewall to clear many encapsulated bacteria in the blood circulation but fail to control certain high-virulence capsule types. Here we report that the spleen is the backup immune organ to clear the liver-resistant serotypes of (pneumococcus), a leading human pathogen.
View Article and Find Full Text PDFJ Epidemiol Glob Health
March 2025
Microbiological Type Culture Collection and Gene Bank (MTCC), CSIR Institute of Microbial Technology, Chandigarh, 160036, India.
Introduction: Antimicrobial resistance (AMR) is one of the major global concerns in the current scenario. Mass-gathering events in fast-developing and densely populated areas may contribute to antibiotic resistance. Despite meticulous planning and infrastructure development, the effect of mass gatherings on microbial ecosystems and antibiotic resistance must be investigated.
View Article and Find Full Text PDFAdv Mater
March 2025
Université de Bretagne Sud, IRDL UMR CNRS 6027, BIONICS group, Lorient, 56100, France.
Biological structures provide inspiration for developing advanced materials from sustainable resources, enabling passive structural morphing. Despite an increasing interest for parsimony-oriented innovation, sustainable shape-changing materials based on renewable resources remain underexplored. In this work, the architecture of a single plant fiber cell wall (S, for instance) is simplified to design novel concepts of 4D printed tubular moisture-driven structural actuators, using the hygromorphic properties of continuous flax fiber (cFF) reinforced materials.
View Article and Find Full Text PDFCells
March 2025
Department of Biology, Developmental Biology, Philipps University Marburg, Karl-von-Frisch Str. 8, 35037 Marburg, Germany.
MicroRNAs function as post-transcriptional regulators in gene expression and control a broad range of biological processes in metazoans. The formation of multinucleated muscles is essential for locomotion, growth, and muscle repair. microRNAs have also emerged as important regulators for muscle development and function.
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