The structural use of fibre-reinforced concrete (FRC) has shown to be an attractive alternative for certain structural elements, being especially suitable to withstand shear stresses in concrete beams. In the case of longitudinal steel bars to support bending stresses, the reductions are of interest. However, in the case of shear stress, it is possible to eliminate the stirrup reinforcement in certain areas. In such a case, the use of FRC may eliminate not only the material but also the tasks of preparing and placing reinforcement, achieving significant savings in labour and allowing a faster execution, avoiding human error, and providing greater security to the work. This study was developed with the aim of assessing a basic practical application of FRC for shear strength. A series of graphics have been made to be used as a calculation tool. The typical structural elements of buildings subjected to bending and shear stress have been tested and analysed. The results for steel fibre-reinforced concrete (SFRC) and polyolefin fibre-reinforced concrete (PFRC) show that fibre can substitute, to some extent, part of the longitudinal reinforcement needed to provide the required flexural strength. Additionally, the fibres can reduce or even eliminate the need for stirrups for shear strength, which leads to savings in cost and execution time.
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http://dx.doi.org/10.3390/ma18040801 | DOI Listing |
Cells
March 2025
School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences & Medicine, King's College London, London SE5 9NU, UK.
Endothelial dysfunction is the main initiating factor in atherosclerosis. Through mechanotransduction, shear stress regulates endothelial cell function in both homeostatic and diseased states. Accumulating evidence reveals that epigenetic changes play critical roles in the etiology of cardiovascular diseases, including atherosclerosis.
View Article and Find Full Text PDFBiotechnol Prog
March 2025
Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA.
The organ transplantation field requires new approaches for replacing and regenerating tissues due to the lack of adequate transplant methods. Three-dimensional (3D) extrusion-based bioprinting is a rapid prototyping approach that can engineer 3D scaffolds for tissue regeneration applications. In this process, 3D printed cell-based constructs, consisting of biomaterials, growth factors, and cells, are formed by the extrusion of bioinks from nozzles.
View Article and Find Full Text PDFCirc Res
March 2025
Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong (M.J., H.D., C.W.L., Y.X., X.Y., Yu Huang).
Background: Atherosclerosis is characterized by the accumulation of fatty and fibrotic plaques, which preferentially develop at curvatures and branches along the arterial trees that are exposed to disturbed flow. However, the mechanisms by which endothelial cells sense disturbed flow are still unclear.
Methods: The partial carotid ligation mouse model was used to investigate disturbed flow-induced atherogenesis.
Front Cell Dev Biol
February 2025
Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
The interaction between integrin αβ and fibronectin enables tumor cell adherence to endothelial layers under diverse hydrodynamic blood flow conditions, particularly in low shear stress regions. Understanding the mechanical binding characteristics between integrin αβ and fibronectin under different hydrodynamic environments can provide insights into tumor cell invasion and proliferation. Here, the adhesive behavior of fibronectin-functionalized microspheres on integrin αβ-coated substrates under various wall fluid shear forces (0.
View Article and Find Full Text PDFBMC Oral Health
March 2025
Division of Prosthodontics, Faculty of Dentistry, Thammasat University, Pathumthani, 12120, Thailand.
Background: Increased bond strength between aged CAD/CAM (Computer-Aided Design and Computer-Aided Manufacturing) provisional restorative materials is essential for reparability. This study investigated the impact of three different solvents and airborne-particle abrasion on the shear bond strength (SBS) of aged CAD/CAM provisional restorative materials, which are milled PMMA and 3D-printed resin with flowable resin composite.
Methods: 3D-printed resin and milled PMMA (N = 160 per type) were fabricated into cylindrical shapes (5 mm in diameter, 5 mm in height), aged by 5,000 thermocycling cycles, and randomize divided at random into five groups (N = 32) based on surface modification protocols: control; non-surface modification, MEK; application with methyl ethyl ketone, THF; application with tetrahydrofuran, Alc; application with isopropyl alcohol, and APA; airborne-particle abrasion with 50-µm alumina oxide particle.
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