There is growing interest in examining acute effects of exercise on cognitive functions and neurocognitive outcomes. These behavioral and neurocognitive outcomes have been most frequently investigated in healthy young individuals, but relatively few studies have examined healthy older adults. This study aimed to systematically review the effects of acute moderate-intensity aerobic exercise (MIAE) on core executive functions, including inhibition, working memory, and cognitive flexibility, in healthy older adults. A database search of PubMed, Scopus, and Web of Science was conducted using a systematic search strategy. Acute MIAE interventions assessing core executive functions using randomized or stratified controlled trials investigating healthy older adults were reviewed. Eleven studies were identified, and the behavioral results from all included studies revealed that acute MIAE can improve core executive functions in healthy adults. However, incompatible results were observed in activated areas of the prefrontal cortex following MIAE in older adults. The limited number of studies investigating the effects of MIAE on core executive functions in older healthy adults with moderate overall quality restricts the conclusions. Therefore, more robust quality studies using neuroimaging techniques to investigate core executive functions, especially working memory and cognitive flexibility, are needed to explain the neural and behavioral mechanisms.
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http://dx.doi.org/10.3390/life15020230 | DOI Listing |
J Am Coll Cardiol
March 2025
Cedars Sinai Medical Center, Los Angeles, California, USA. Electronic address:
This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic valve failure in a practical, imaging directed context for TAVR.
View Article and Find Full Text PDFFront Comput Neurosci
February 2025
Department of Neurology, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Background: Depressive disorders are one of the most common mental disorders among young people. However, there is still a lack of objective means to identify and evaluate young people with depressive disorders quickly. Cognitive impairment is one of the core characteristics of depressive disorders, which is of great value in the identification and evaluation of young people with depressive disorders.
View Article and Find Full Text PDFInt J Cardiol
March 2025
HerzZentrum Hirslanden, Zurich, Switzerland.
Aims: To assess the association between right heart failure (RHF) and mortality in patients with severe tricuspid regurgitation (TR) undergoing transcatheter tricuspid valve intervention (TTVI), and to determine whether clinical RHF status reduces the survival benefit of successful versus failed TTVI.
Methods And Results: The TriValve International Registry (Transcatheter Tricuspid Valve Therapies) is a multicenter registry collecting data of patients with symptomatic, severe or greater TR undergoing TTVI. The population was stratified according to RHF status defined by the following clinical criteria: history of previous hospitalization for RHF (<1 year) OR presence of signs of RHF (jugular venous distension, ascites, peripheral oedema) OR high dose diuretic (≥125 mg/day of furosemide or equivalent).
Chin Med J (Engl)
March 2025
Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Background: Growing evidence suggests that long non-coding RNAs (lncRNAs) exert pivotal roles in fostering chemoresistance across diverse tumors. Nevertheless, the precise involvement of lncRNAs in modulating chemoresistance within the context of gallbladder cancer (GBC) remains obscure. This study aimed to uncover how lncRNAs regulate chemoresistance in gallbladder cancer, offering potential targets to overcome drug resistance.
View Article and Find Full Text PDFJ Thromb Thrombolysis
March 2025
Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
COVID-19 is associated with an increased risk of venous thromboembolism (VTE) in hospitalized patients. Although prior studies have attempted to identify predictors of VTE, restricted sample size and use of administrative claims data have limited such analyses. We utilized data from hospitalized patients in the CORONA-VTE Network, a United States multicenter registry of adult patients with PCR-confirmed COVID-19 (N = 3,844).
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