Background: Arteriovenous fistula (AVF) is the preferred vascular access option for hemodialysis (HD). The latter requires a remodeling process called maturation that can take up to 3 months. Maturation failure is a frequent complication associated with significant morbidity. The prevalence of antiphospholipid antibody (aPL) positivity in HD patients is high and may result in thrombosis of the vascular access. Recently, aPL persistent positivity has been associated with AVF maturation failure in a retrospective study including 116 patients.
Methods: We are conducting an observational prospective cohort study aiming to evaluate this association. Included patients are planned for AVF creation, aged over 18 years old, and have an interpretable aPL assay confirmed at 12 weeks and without any other innate or acquired thrombophilia or inflammatory disease. Primary endpoints will be the evaluation of AVF maturation clinically and by ultrasound. Secondary endpoints will focus on clinical outcomes other than AVF maturation (i.e., primary patency, thrombosis or stenosis, bleeding and hemodialysis adequacy parameters).
Conclusions: This prospective observational cohort study aims to examine the possibly causative link between aPL persistent positivity and AVF maturation failure. This study was registered on ClinicalTrials.gov (ID number: NCT06112821).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856552 | PMC |
| http://dx.doi.org/10.3390/life15020168 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vessel Diameter and Radiocephalic Arteriovenous Fistula: A Meta-Analysis and Markov Model.
J Vasc Surg
March 2025
Department of Renal Surgery, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, UK.
Objective: To determine the optimal radial artery (RA) and cephalic vein (CV) diameter for the best functional maturation (FM) of Radiocephalic Arteriovenous Fistula (RCAVF) with their financial implication.
Methods: A systematic review and meta-analysis following PRISMA guidelines included n =4,610 patients. The data was initially subjected to Pearson correlation to evaluate success-to-failure ratios on the endpoint of FM, to rule out the impact of confounders.
Association of Surgeon Volume and Operative Factors with Early Thrombosis of Arteriovenous Fistulas for Hemodialysis.
J Vasc Surg
February 2025
Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA. Electronic address:
Background: While arteriovenous fistula (AVF) is the ideal initial option for hemodialysis access, failure can occur due to early thrombosis or lack of maturation. Surgeon volume has previously been associated with higher rates of maturation, but the relationship between volume and early thrombosis remains unknown.
Methods: All adults undergoing cephalic based AVF between 2014 and 2019 were identified from five safety net hospitals within the Los Angeles County Department of Health Services system.
Risk score for the prediction of arteriovenous fistula maturation.
J Vasc Surg
February 2025
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore 119228, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Health System 119228, Singapore. Electronic address:
Background: The poor maturation rate of arteriovenous fistulas (AVF) remains a challenge. We aim to develop a parsimonious risk score equations that incorporate patients' demographics, comorbidities, and vessel characteristics to assist the access surgeons in predicting the likelihood of AVF maturation before surgery.
Methods: Data of AVFs created from 2015 to 2020 in National University Hospital Singapore was retrospectively obtained and used as the training dataset.
Assessment of Arteriovenous Fistula Maturation in Hemodialysis Patients with Persistently Positive Antiphospholipid Antibody: A Prospective Observational Cohort Study.
Life (Basel)
January 2025
Nephrology and Dialysis Department, Brugmann University Hospital, Université Libre de Bruxelles (ULB), 1020 Brussels, Belgium.
Background: Arteriovenous fistula (AVF) is the preferred vascular access option for hemodialysis (HD). The latter requires a remodeling process called maturation that can take up to 3 months. Maturation failure is a frequent complication associated with significant morbidity.
View Article and Find Full Text PDFThe role of cellular senescence in endothelial dysfunction and vascular remodelling in arteriovenous fistula maturation.
J Physiol
February 2025
Center for Biomedical Research (CIBMED), Faculty of Medicine, Universidad Finis Terrae, Santiago, Chile.
Haemodialysis (HD) is often required for patients with end-stage renal disease. Arteriovenous fistulas (AVFs), a surgical procedure connecting an artery to a vein, are the preferred vascular access for HD due to their durability and lower complication rates. The aim of AVFs is to promote vein remodelling to accommodate increased blood flow needed for dialysis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!