To assess a subject with multiple factors or attributes, a comprehensive evaluation index, or say a composite indicator, is often constructed to make a holistic judgement. The key problem is to assign weights to the factors. There are various weighting methods in the literature, but a gold standard is lacking. Some weighting methods may lead to a trivial weight assignment that is one factor having a weight equal to 1 and the others all zero, while some methods generate a solution contradicting intuitive judgement, or even infeasible to calculate. This paper proposes a new model to generate weights based on the maximum entropy-minimum residual (MEMR) principle, directly estimating the relationship between factor weights and the composite indicator. The MEMR composite indicator extracts the common feature of multiple factors while preserving their diversity. This paper compares the MEMR model with other commonly used weighting methods in various case studies. The MEMR model has more robust, consistent, and interpretable results than others and is suitable for all comprehensive evaluation cases involving quantitative factors. The optimization technique of the proposed MEMR model and the related statistical tests are included as a package in the DPS (data processing system) software V21.05 for the convenience of application in all fields.
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http://dx.doi.org/10.3390/e27020203 | DOI Listing |
Clin Transl Allergy
March 2025
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Background: This study aimed to comprehensively characterize the gut microbiome and identify individual and grouped gut microbes associated with food allergy (FA) using 16S rRNA gene sequencing.
Methods: Fecal samples were collected from children with IgE-mediated FA and from sex- and age-matched controls. The V3-V4 variable regions of the 16S rRNA gene of the gut microbiome were profiled using next-generation sequencing (Illumina, USA).
Ann Med
December 2025
Department of Assisted Reproductive Centre, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Background: Butyrate may inhibit SARS-CoV-2 replication and affect the development of COVID-19. However, there have been no systematic comprehensive analyses of the role of butyrate metabolism-related genes (BMRGs) in COVID-19.
Methods: We performed differential expression analysis of BMRGs in the brain, liver and pancreas of COVID-19 patients and controls in GSE157852 and GSE151803.
ACS Appl Bio Mater
March 2025
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India.
Multidrug resistance (MDR) infectious wounds are a major concern due to drug resistance, leading to increased patient morbidity. Lichenysin (LCN), a lipopeptide and biosurfactant obtained from certain strains of , has demonstrated an excellent antimicrobial property. The present study focuses on the fabrication and comprehensive evaluation of LCN-incorporated poly(vinyl alcohol) (PVA)/polycaprolactone (PCL)-based nanofiber scaffolds using an electrospinning technique as a potential wound healing biomaterial for the treatment of MDR infectious wounds in diabetic rats.
View Article and Find Full Text PDFJ Prev Alzheimers Dis
March 2025
Department of Pathophysiology School of Basic Medicine Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Background: The swift rise in the prevalence of Alzheimer's disease (AD) alongside its significant societal and economic impact has created a pressing demand for effective interventions and treatments. However, there are no available treatments that can modify the progression of the disease.
Methods: Eight AD brain tissues datasets and three blood datasets were obtained.
Rev Environ Health
March 2025
Public Health Department- Dubai Health Authority, Dubai, United Arab Emirates.
Introduction: The developing brain, especially vulnerable during neuroplastic phases, is influenced by environmental and genetic factors. Understanding the impacts of air pollution on children's and young adults' mental health is an emerging research field.
Content: This review systematically examines the adverse associations of ambient air pollutants on mental health.
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