Surgical wound infections are a major cause of postoperative complications, contributing to surgical morbidity and mortality. With the rise of antibiotic-resistant pathogens, it is crucial to develop new innovative wound materials to manage surgical wound infections using methods that facilitate drug delivery agents and rely on materials other than antimicrobials. Nanoparticles, in particular, have captured researchers' interest in recent years due to their effectiveness in wound care. They can be classified into three main types: inorganic nanoparticles, lipid-based nanoparticles, and polymeric nanoparticles. Several studies have demonstrated the effectiveness of these new technologies in enhancing wound-healing times and reducing bacterial burden. However, further research is essential to thoroughly evaluate the safety and toxicity of these materials before they can be integrated into routine surgical practice.
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http://dx.doi.org/10.3390/bioengineering12020137 | DOI Listing |
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Second Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Incisional hernia of abdominal wall is one of the most common complications following open surgery. Giant incisional hernia of abdominal wall is defined as having a maximum defect diameter >12 cm or a hernia sac volume-to-abdominal cavity volume ratio >20%. The Primary treatment for giant incisional hernia of abdominal wall is surgical repair; however, both open surgery and conventional laparoscopic surgery are associated with significant technical difficulty, high surgical trauma, frequent postoperative complications, and suboptimal outcomes.
View Article and Find Full Text PDFAnn Vasc Surg
March 2025
Harbor UCLA Medical Center, Department of Surgery, Division of Vascular Surgery, 1000 W Carson St, Torrance CA 90502.
Background: Frailty has been reported as a predictor of adverse outcomes after various surgical procedures. There are several models for defining frailty, including 5-factor modified frailty index, clinical frailty scale, and psoas muscle index. Low psoas muscle index has been associated with higher postoperative mortality and complications after various surgical procedures.
View Article and Find Full Text PDFInjury
March 2025
Department of Orthopaedic Surgery, University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH 44106, USA.
Introduction: Serotonergic antidepressants, including both selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have been linked to adverse outcomes following orthopedic procedures. This study aims to evaluate the impact of SSRIs/SNRIs on outcomes in patients following operative fixation of the femur. We hypothesized that perioperative use of SSRIs would be associated with worse outcomes post-surgery.
View Article and Find Full Text PDFJ Am Acad Orthop Surg
March 2025
From the Yale School of Medicine, New Haven, CT (Kammien and Yu), theDivision of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (Zhao and Colen), and Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT (Grauer).
Background: Single-institution studies demonstrate reduced cost and similar outcomes for wide-awake fasciectomy compared with those with standard anesthesia. This retrospective cohort study examines these findings on a national level, comparing adverse events and cost for partial fasciectomies performed wide-awake and with standard anesthesia.
Methods: Partial fasciectomies were identified in the 2010-2022 PearlDiver database.
PLoS One
March 2025
Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Periprosthetic joint infections (PJI), along with the extensive medical and surgical interventions required for treatment, impose a substantial psychological burden on patients. Given the need for patients to adapt to long-term physical limitations and ongoing medical challenges, this qualitative study aims to explore the nature of psychological coping amongst patients with chronic cases of PJI. A total of 18 patients (8 men and 10 women, aged 55 to 92) who underwent a total knee or hip arthroplasty revision due to chronic PJI were recruited at a single academic institution between August 2022 and July 2023.
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