Dementia with Lewy bodies (DLB) can be diagnosed through a combination of clinical criteria, the loss of dopaminergic neuron terminals in presynaptic [123I]FP-CIT SPECT dopaminergic imaging, and diffuse [18F]FDG PET hypometabolism, which typically affects also the visual cortex. A 360-degree CZT SPECT systems offer advantages in terms of count sensitivity, and both contrast and energy resolution for perfusion and dopaminergic imaging as compared with conventional SPECT systems. As it happens for PET imaging protocols, a dual-time-window protocol with CZT SPECT imaging was used for a suspected DLB patient to capture both perfusion and dopaminergic states.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/RLU.0000000000005764 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Early Perfusion [123I]FP-CIT SPECT Imaging With a 360-degree CZT Camera in Dementia With Lewy Bodies.
Clin Nucl Med
February 2025
Unit of Nuclear Medicine, Department of Medicine (DIMED), University Hospital of Padova, Padua, Italy.
Dementia with Lewy bodies (DLB) can be diagnosed through a combination of clinical criteria, the loss of dopaminergic neuron terminals in presynaptic [123I]FP-CIT SPECT dopaminergic imaging, and diffuse [18F]FDG PET hypometabolism, which typically affects also the visual cortex. A 360-degree CZT SPECT systems offer advantages in terms of count sensitivity, and both contrast and energy resolution for perfusion and dopaminergic imaging as compared with conventional SPECT systems. As it happens for PET imaging protocols, a dual-time-window protocol with CZT SPECT imaging was used for a suspected DLB patient to capture both perfusion and dopaminergic states.
View Article and Find Full Text PDFJustification and impact of SPECT ¹²³I-FP-CIT use in the differential diagnosis and management of movement disorders (MD) in a national referral hospital.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
February 2025
Servicio de Medicina Nuclear, Hospital Universitario 12 de Octubre, Madrid, Spain.
Unlabelled: I-FP-CIT SPECT is a key tool in the differential diagnosis of movement disorders (MD), but its appropriate indication is essential to optimize resources and avoid unnecessary tests.
Aim: To evaluate the adequacy and impact of I-FP-CIT SPECT in the diagnosis and management of MD according to clinical guidelines.
Patients And Methods: Retrospective study involving 249 patients with suspected parkinsonism (PK) of uncertain origin.
Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies.
Sci Rep
February 2025
IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Nigrostriatal dopaminergic degeneration in alpha-synucleinopathies is indirectly reflected by low dopamine transporter (DaT) uptake through [123I]FP-CIT-SPECT. Bulk magnetic susceptibility (χ) in the substantia nigra, from MRI-based quantitative susceptibility mapping (QSM), is a potential biomarker of nigrostriatal degeneration, however, QSM cannot disentangle paramagnetic (e.g.
View Article and Find Full Text PDFDetection of the Cingulate Island Sign by Early Perfusion Imaging in Dopamine Transporter SPECT With Multiple-Pinhole Collimators.
Clin Nucl Med
February 2025
From the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Multiple-pinhole collimators provide considerable improvement of SPECT system count sensitivity. This case report suggests that SPECT with brain-specific multiple-pinhole collimators enables cerebral perfusion imaging with diagnostic quality by an early 12 minutes scan immediately after injection of a standard dose of the dopamine transporter ligand 123I-FP-CIT. Thus, 123I-FP-CIT SPECT with multiple-pinhole collimators could assess nigrostriatal degeneration (late image) and extrastriatal involvement (early perfusion image) during the same imaging session.
View Article and Find Full Text PDFNeural substrates underlying distinct dual cognitive syndromes in Parkinson's disease.
Eur J Neurol
January 2025
Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Background: A dual-syndrome hypothesis, which states the cognitive impairments in Parkinson's disease (PD) are attributable to frontostriatal dopaminergic dysregulation and cortical disturbance-each associated with attention/executive and memory/visuospatial dysfunction, respectively-has been widely accepted. This multisystem contribution also underlies highly heterogeneous progression rate to dementia.
Methods: Nondemented PD patients who underwent [I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([I]FP-CIT) SPECT and neuropsychological examinations were enrolled.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!