Objective: To evaluate the effectiveness and cost-effectiveness of physiotherapy, chiropractic care, and the combination of physiotherapy and chiropractic care compared with information and advice for the treatment of patients with nonspecific chronic low-back pain (CLBP) in Sweden.
Design: A multicentre pragmatic randomized controlled trial.
Setting: Ten primary care rehabilitation units in Sweden.
Participants: Eighty-eight participants with nonspecific CLBP.
Interventions: The participants were randomly assigned to receive physiotherapy, chiropractic care, combination treatment, or information and advice.
Main Outcome Measures: This study measured the Oswestry Disability Index (ODI), health-related quality of life (HRQoL), quality-adjusted life-years (QALYs), working status, and costs.
Results: The study revealed no statistically significant differences in any of the outcome measures when physiotherapy, chiropractic care, and combination treatment with information and advice were compared (p > 0.05). The ODI changes between baseline and the 6-month follow-up ranged from 6.13 to 12.56 across the treatment groups, indicating reduced disability in all groups. Compared with the other treatment options, the combination treatment resulted in the greatest QALY gain (0.418) and lowest cost (SEK 3,081).
Conclusion: Compared with alternative standalone treatment options, the combination treatment strategy resulted in greater QALY gain and lower costs from a heath care perspective. Although the study did not detect statistically significant differences in outcomes or costs among the treatment options, the combination treatment showed promising potential for cost-effectiveness. Given the small sample size and low statistical power of the study, further clinical trials with fewer treatment arms and a focus on the combination group are warranted to confirm these findings. The insights gained from this study are important for informing the design and conduct of future clinical studies investigating the effectiveness, costs and cost-effectiveness of treatments for CLBP.
Trial Registration: The study is registered in the ISRCTN registry (2017-02-20: ISRCTN15830360).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853996 | PMC |
| http://dx.doi.org/10.1186/s12891-025-08392-7 | DOI Listing |
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