Suppose in a stable urban traffic system populated only by human driven vehicles (HDVs), a given proportion (e.g. [Formula: see text]) is replaced by a fleet of Connected and Autonomous Vehicles (CAVs), which share information and pursue a collective goal. Suppose these vehicles are centrally coordinated and differ from HDVs only by their collective capacities allowing them to make more efficient routing decisions before the travel on a given day begins. Suppose there is a choice between two routes and every day each driver makes a decision which route to take. Human drivers maximize their utility. CAVs might optimize different goals, such as the total travel time of the fleet. We show that in this plausible futuristic setting, the strategy CAVs are allowed to adopt may result in human drivers either benefitting or being systematically disadvantaged and urban networks becoming more or less optimal. Consequently, some regulatory measures might become indispensable.
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http://dx.doi.org/10.1038/s41598-025-90783-w | DOI Listing |
Camb Prism Extinct
May 2024
School of Natural Sciences, University of Tasmania, Hobart, TAS, Australia.
Patterns of extinction risk can vary across taxa, with species of some groups being particularly vulnerable to extinction. Rails (Aves: Rallidae) represent one of the most extreme yet well-documented cases of mass extinction within a modern vertebrate group. Between 54 and 92% of rail species became extinct following waves of human contact during both the Holocene and the Anthropocene eras, and a third of the extant species are currently threatened or near-threatened.
View Article and Find Full Text PDFCamb Prism Extinct
March 2024
Center for Ecological Dynamics in a Novel Biosphere (ECONOVO) & Center for Biodiversity Dynamics in a Changing World (BIOCHANGE), Department of Biology, Aarhus University, Aarhus, Denmark.
Across the last ~50,000 years (the late Quaternary) terrestrial vertebrate faunas have experienced severe losses of large species (megafauna), with most extinctions occurring in the Late Pleistocene and Early to Middle Holocene. Debate on the causes has been ongoing for over 200 years, intensifying from the 1960s onward. Here, we outline criteria that any causal hypothesis needs to account for.
View Article and Find Full Text PDFJ Evol Biol
March 2025
Integrative Biology, University of California - Berkeley, Berkeley, CA 94720, USA.
Given their ubiquity in nature and their importance to human and agricultural health it is important to gain a better understanding of the drivers of the evolution of infectious disease. Across vertebrates, invertebrates and plants, defence mechanisms can be expressed either constitutively (always present and costly) or induced (activated and potentially costly only upon infection). Theory has shown that this distinction has important implications to the evolution of defence due to differences in their impact on both individual fitness and the feedback of the population level epidemiological outcomes such as prevalence.
View Article and Find Full Text PDFInt J Mol Sci
March 2025
Escuela de Medicina, Universidad de Tarapacá, Arica 1000000, Chile.
Rosacea is a common chronic inflammatory condition primarily affecting middle-aged women. It presents with flushing, erythema, telangiectasia, papules, pustules, phymatous changes, and ocular involvement. Although typically grouped into four subtypes-erythematotelangiectatic, papulopustular, ocular, and phymatous-overlapping features often favor a phenotypic diagnostic approach.
View Article and Find Full Text PDFInt J Mol Sci
March 2025
Department of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.
The liver is the most lethal metastatic site in castration-resistant prostate cancer (CRPC). Overexpression of MET protein has been reported in CRPC, and is an important driver gene in androgen-independent CRPC cells. Mouse CRPC cell line CRTC2 was established by subcutaneous injection of hormone-sensitive PC cells (TRAMP-C2) in castrated nude mice.
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