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We present a case of a 65-year-old woman diagnosed with mixed mucinous-invasive ductal carcinoma, a rare subtype of breast cancer. Utilizing 99mTc-FAPI-46 scintigraphy, we observed a high target-to-background ratio in the breast mass and metastatic axillary lymph nodes. Notably, a benign follicular nodule was also detected in the thyroid which showed absent 99mTc-FAPI uptake.
View Article and Find Full Text PDFCytologic Diagnoses of Lung Adenocarcinoma With Concomitant Metastasis From a Different Primary: A Case Series.
Diagn Cytopathol
March 2025
University of Virginia School of Medicine Inova Campus, Falls Church, Virginia, USA.
Lung adenocarcinoma is a common malignancy that can metastasize. The lung is also a common site for metastasis from other sites. Prompt and accurate diagnosis is critical for patient management.
View Article and Find Full Text PDFImmunofluorescent analysis of exosomes using a microchip filled with transparent antibody-conjugated beads for breast cancer liquid biopsy.
Anal Chim Acta
April 2025
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China. Electronic address:
Background: Exosomes represent optimal biomarkers for liquid biopsy. Current exosome-based methods are still limited by isolation methods, long processing times, complex structure, low accuracy, large sample volume consumption, and the influence of chemical reagents on the analysis results.
Result: To overcome these challenges, a novel microfluidic approach that employs continuous, rapid, and efficient processes is proposed for the capture and enriching exosomes using the optical transparent antibody-conjugated microbeads within the chip.
[Breast mucinous cystadenocarcinoma: A case report].
Ann Pathol
February 2025
Unité d'anatomie et de cytologie pathologiques, Centre Georges-François-Leclerc, 1, rue du Pr Marion, 21000 Dijon, France.
FOXA1 expression and its association with mucin expression and KRAS mutation in ovarian mucinous tumors: implications for tumor progression and differentiation.
Virchows Arch
January 2025
Department of Human Pathology, Faculty of Medicine, Juntendo University, Tokyo, Japan.
This study aimed to investigate forkhead box A1 (FOXA1) expression in ovarian mucinous tumors and its association with mucin expression and KRAS mutation status to clarify its role in tumor progression and differentiation. We analyzed 57 normal tissues or benign ovarian lesions, 110 mucinous ovarian tumors, including mucinous carcinomas, and 214 other ovarian epithelial carcinomas using immunohistochemistry for FOXA1, MUC2, MUC5AC, and MUC6. We also performed KRAS mutation analysis.
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