Cerebral hemorrhage is a serious cerebrovascular disease with high morbidity and high mortality, for which timely diagnosis and treatment are crucial. Electrical impedance tomography (EIT) is a functional imaging technique which is able to detect abnormal changes of electrical property of the brain tissue at the early stage of the disease. However, irregular multi-layer structure and different conductivity properties of each layer affect image reconstruction of the brain EIT, resulting in low reconstruction quality. To solve this problem, an image reconstruction method based on an improved densely-connected fully convolutional neural network is proposed in this paper. On the basis of constructing a three-layer cerebral model that approximates the real structure of the human head, the nonlinear mapping between the boundary voltage and the conductivity change is determined by network training, which avoids the error caused by the traditional sensitivity matrix method used for solving inverse problem. The proposed method is also evaluated under the conditions with or without noise, as well as with brain model change. The numerical simulation and phantom experimental results show that conductivity distribution of cerebral hemorrhage can be accurately reconstructed with the proposed method, providing a reliable basis for the diagnosis and treatment of cerebral hemorrhage. Also, it promotes the application of EIT in the diagnosis of brain diseases.
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http://dx.doi.org/10.7507/1001-5515.202406044 | DOI Listing |
Cureus
February 2025
Internal Medicine, Farwaniya Hospital, Kuwait City, KWT.
Moyamoya disease (MMD) is a rare, progressive cerebrovascular disorder characterized by the bilateral stenosis of the internal carotid artery (ICA) and its proximal vessels, leading to the formation of compensatory smoke-like collateral vessels. This report describes the case of a 33-year-old Philippine woman who presented with acute right-sided hemiparesis and had a history of recurrent transient ischemic attacks (TIAs) with similar symptoms. Neuroimaging revealed intracranial hemorrhage and characteristic bilateral occlusion of the internal carotid artery (ICA), middle cerebral artery (MCA), and anterior cerebral artery (ACA) with collateral vessel formation, indicative of moyamoya disease.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Neurobiology, Research Unit, Hospital Universitari Son Espases, Health Research Institute of Balearic Islands (IdISBa), 07120 Palma, Spain.
Pediatric stroke, a significant cause of long-term neurological deficits in children, often arises from disruptions within neurovascular unit (NVU) components. The NVU, a dynamic ensemble of astrocytes, endothelial cells, pericytes, and microglia, is vital for maintaining cerebral homeostasis and regulating vascular brain development. Its structural integrity, particularly at the blood-brain barrier (BBB), depends on intercellular junctions and the basement membrane, which together restrict paracellular transport and shield the brain from systemic insults.
View Article and Find Full Text PDFActa Neurochir (Wien)
March 2025
Department of Neurosurgery, Aalborg University Hospital, Aalborg, Denmark.
Background: Multimodal neuromonitoring (MMM) aids early detection of secondary brain injury in neurointensive care and facilitates research in pathophysiologic mechanisms of the injured brain. Invasive ICP monitoring has been the gold standard for decades, however additional methods exist (aMMM). It was hypothesized that local practices regarding aMMM vary considerably and that inter-and intracenter consensus is low.
View Article and Find Full Text PDFMed Gas Res
March 2025
Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Many patients experience long-term cognitive dysfunction after subarachnoid hemorrhage (SAH), and effective treatments are currently lacking. Carbon dioxide (CO2), an inexpensive and easily produced gas, forms carbonic acid when dissolved in water. Studies have suggested that hypercapnia may have neuroprotective effects.
View Article and Find Full Text PDFAnimal Model Exp Med
March 2025
Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Background: Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)-based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation. The role of miR-21 in NSC differentiation and proliferation during ICH recovery remains unexplored.
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