The type of phenolic compounds significantly influences the physicochemical properties and biological activities of packaging materials. This study aimed to investigate the effects of caffeic acid (Caf), esculetin (Esc), or quercetin (Que) on the physicochemical and antioxidant properties of polylactic acid/modified cellulose nanocrystals (PM) nanofiber film. FTIR and XRD analyses confirmed the successful encapsulation of Caf, Esc, and Que. in the PM films. Incorporating these phenolic compounds enhanced PM's water vapor barrier and surface hydrophobicity. Additionally, Esc improved the tensile strength by 26 % without sacrificing the elongation at break of the PM. Notably, the PM/Caf, PM/Esc, and PM/Que. films exhibited high antioxidant capacity and excellent storage stability (stable within 60 days). Finally, three antioxidant packaging films effectively delayed lipid oxidation and protein degradation in pork and maintained meat color. These resluts suggest that the developed PM/Caf, PM/Esc, and PM/Que. films have potential applications in active food packaging.
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http://dx.doi.org/10.1016/j.foodchem.2025.143514 | DOI Listing |
J Hazard Mater
March 2025
The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address:
The large-scale use of nonrenewable plastic mulch has resulted in serious agricultural health pollution. Biobased plastic materials with degradable properties offer attractive sustainable alternatives, but the shortcomings of their properties are slow degradation and extremely monofunctional, making their full-scale promotion still challenging. This work proposes a novel functionalized strategy for the multifunctionality empowerment of bio-based PLA materials for environmental protection and crop yield enhancement.
View Article and Find Full Text PDFInt J Nanomedicine
March 2025
Department of Vascular Surgery, the second Xiangya Hospital, Central South University, Changsha, 410011, People's Republic of China.
Introduction: Arteriovenous graft (AVG) is an important option for establishing hemodialysis access in patients with end-stage chronic kidney disease (CKD). Decellularized tissue-engineered vascular graft (dTEVG), due to its excellent biocompatibility and regenerative potential, holds promise for use in AVG; however, poor remodeling remains a challenge. Quercetin (Qu) can effectively regulate macrophage polarization and promote tissue remodeling and regeneration, yet its low bioavailability limits its clinical application.
View Article and Find Full Text PDFEnviron Int
March 2025
School of Environment, Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control, Ministry of Education, Henan Normal University, Xinxiang 453007, China; Huanghuai Laboratory, Zhengzhou, Henan 450003, China. Electronic address:
This study examined the effects of hot high-fat simulants on the physicochemical properties of microplastics (MPs) from polypropylene (PP)-, low-density polyethylene (LDPE)-, and polylactic acid (PLA)-based single-use food container (SUFC) leachates and those of aging on their immunomodulatory effectors. Scenario studies have demonstrated that MPs were released from these three types of SUFCs. LDPE- and PLA-based SUFCs also released cellulose.
View Article and Find Full Text PDFDrug Deliv
December 2025
Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA.
A clinical need exists for more effective intravitreal (IVT) drug delivery systems (DDS). This study tested the hypothesis that a novel biodegradable, injectable microsphere-hydrogel drug delivery system loaded with aflibercept (aflibercept-DDS) would exhibit long-term safety and biocompatibility in a non-human primate (NHP) model. We generated aflibercept-loaded poly (lactic-co-glycolic acid) microparticles with a modified double emulsion technique then embedded them into a biodegradable, thermo-responsive poly (ethylene glycol)-co-(L-lactic-acid) diacrylate/N-isopropylacrylamide hydrogel.
View Article and Find Full Text PDFJ Oleo Sci
March 2025
Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University.
Among primary brain tumors, glioma has one of the highest fatality rates. Routine chemotherapy often faces off-target drug loss and sub-optimal drug availability at brain tissue. The present study aims at the development of transferrin-conjugated gemcitabine loaded poly (lactic co glycolic acid) nanoparticles (Tf-GB-PLGA-NPs) targeted strategy for brain cancer cell.
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