Lead exposure poses severe health risks to individuals, impacting cognitive function, growth, learning, and behavior. Current lead detection methods, primarily blood testing and x-ray fluorescence (XRF) of bone, have limitations. This study introduces a novel in vivo XRF measurement system using K-shell energies of lead, addressing limitations of previous methods. The study aimed to characterize beam directionality, subject radiation dose, and operator occupational exposure. Using a high-energy x-ray tube and room-temperature detectors, various parameters were assessed with bone and tissue phantoms. Dose measurements were taken by altering voltage, current, and shielding. Scatter and spatial measurements highlighted increased scatter with bone and tissue presence, emphasizing the safest positions for bystanders and operators. Results exhibited expected dose rate changes with varying parameters, showcasing the impact of bone and tissue on scatter radiation. The system's total body effective dose (with an 8-mm molybdenum shielding indicating minimal risk compared to established public dose limits) for an adult was 1.94 μSv; for a child aged 10 y, it was 3.28 μSv. This system demonstrates promising capabilities for lead exposure monitoring, offering negligible occupational exposure and minimal risk to individuals being scanned. Its safety and efficacy position it as a valuable tool in assessing lead exposure, potentially improving preventive measures.
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http://dx.doi.org/10.1097/HP.0000000000001839 | DOI Listing |
Int J Pharm
March 2025
Department of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.
Laboratory-scale spray drying can be a useful tool in developing new dry powder formulations for the delivery of biologics such as therapeutic proteins or vaccines. Low-temperature drying is often used in these processes to prevent the exposure of biologics to harsh conditions that could potentially lead to degradation or instability of the final product. However, low-temperature drying on small-scale equipment can result in very low production rates that may not be practical for generating sufficient material for studies requiring larger sample quantities, such as key preclinical or toxicology studies.
View Article and Find Full Text PDFEcotoxicol Environ Saf
March 2025
Department of Health Management, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering Laboratory for Health Management, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, China; Department of Medical Record Management and Statistics, The First Affiliated Hospital of Shandong First Medical University &Shandong Provincial Qianfoshan Hospital, Jinan, China. Electronic address:
Background: High oxidative balance score (OBS) may mitigate inflammation levels and thereby alleviate the adverse health effects induced by toxic metals. We assessed the independent, joint effects as well as their interactions of toxic metals and OBS on mortality among individuals with non-alcoholic fatty liver diseases (NAFLD).
Methods: Participants with NAFLD from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were included.
Environ Sci Pollut Res Int
March 2025
Department of Environmental Medicine, Faculty of Public Health, Institute of Health Protection, Slovak Medical University in Bratislava, Limbová 2651/12, 833 03, Bratislava, Slovakia.
Approximately 5 years ago, we proposed the establishment of a new category of ototoxicants: environmental ototoxicants, in addition to the recognized categories of occupational and drug-related ototoxicants. Since the publication of our review, the scientific literature has confirmed the potential for hearing impairment (HI) caused by the general population's exposure to various chemicals. However, the extent of this exposure's contribution to the global incidence of hearing loss (HL) has yet to be estimated.
View Article and Find Full Text PDFNanomaterials (Basel)
March 2025
Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy.
The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence of micro- (MPs) and nanosized (NPs) plastic particles. MPs and NPs are thus widely present in water and air and inevitably enter the food chain, with inhalation and ingestion as the main exposure routes for humans. Many recent studies have demonstrated that MPs and NPs gain access to several body compartments, where they are taken up by cells, increase the production of reactive oxygen species, and lead to inflammatory changes.
View Article and Find Full Text PDFImmunol Rev
March 2025
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Asthma is one of the most prevalent and extensively studied chronic respiratory conditions, yet the heterogeneity of asthma remains biologically puzzling. Established factors like exogenous exposures and treatment adherence contribute to variability in asthma risk and clinical outcomes. It is also clear that the endogenous factors of genetics and immune system response patterns play key roles in asthma.
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