Aims: While the exacerbating effect of physical exercise and its correlation with arrhythmic outcomes have been demonstrated for Arrhythmogenic Right Ventricular Cardiomyopathy, the impact of physical exercise on other forms of cardiomyopathies is poorly characterized. This study aimed to investigate the relationship between lifelong exercise intensity and the development of cardiac manifestations in subjects carrying a Likely Pathogenic (LP) or Pathogenic (P) truncating variant of titin (TTNtv).
Methods: TTNtv carriers - patients and family members - were interviewed regarding their exercise habits from birth until diagnosis (type of activity, hours/week, weeks/months, months/years, and number of years of exercise). Those engaging in ≥4 hours of vigorous exercise per week (equivalent to ≥1440 METs×minutes/week) for a minimum of 6 years were classified as Athletes. All others were classified as Non-athletes.The correlation between vigorous physical activity and the development of left ventricular systolic dysfunction (LVSD), defined as left ventricular ejection fraction below 45% (LVEF <45%), was explored. Additionally, secondary endpoints included the occurrence of life-threatening ventricular arrhythmias (LTA - i.e., aborted cardiac arrest due to hyperkinetic arrhythmias, documented sustained ventricular tachycardia - SVT -, or appropriate implantable cardioverter-defibrillator therapy), non-LTA ventricular arrhythmias (i.e., >1000 premature ventricular complexes/24h and/or non-sustained ventricular tachycardia - NSVT), and the development of atrial fibrillation and/or atrial flutter (AF/AFL) during follow-up.
Results: Among the 117 subjects (73% male, median age 45 - IQR 35-57 years), 38 (32%) were Athletes. Vigorous exercise was not associated with the development of LVEF <45% (adjusted OR 0.663, 95%CI 0.261-1.685, p 0.388), nor with the occurrence of LTA (p = 0.607), non-LTA (p = 0.648), and supraventricular arrhythmias (p = 0.701). Comparable results were obtained when considering the total amount of METs x hours/life burned by subjects as a continuous variable.
Conclusion: In carriers of TTNtv, vigorous physical activity was not associated with LVSD and LTA development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/eurjpc/zwaf094 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of a Supervised Exercise Program on Pain, Physical Function, and Quality of Life in Patients With Breast Cancer: Protocol for a Randomized Clinical Trial.
JMIR Res Protoc
March 2025
Paseo de los Encomendadores, Faculty of Health Sciences, University of Burgos, Burgos, Spain.
Background: Breast cancer is the second most common cancer in women worldwide. Treatments for this disease often result in side effects such as pain, fatigue, loss of muscle mass, and reduced quality of life. Physical exercise has been shown to effectively mitigate these side effects and improve the quality of life in patients with breast cancer.
View Article and Find Full Text PDFContribution of walking to and from school on overall physical activity: a one-year follow up study.
PLoS One
March 2025
Faculty of Education, Mie University, Mie, Japan.
This study is the first in Japan to prospectively examine the relationship between walking to and from school and physical activity in primary school children. A total of 76 participants completed baseline and follow-up assessments, and their mean age was 9.6 ± 1.
View Article and Find Full Text PDFSoft tissue manipulation enhances recovery of muscle mass in a disuse model of sarcopenia.
J Osteopath Med
March 2025
Wood College of Osteopathic Medicine, Marian University, Indianapolis, IN, USA.
Context: Sarcopenia is a disease characterized by low muscle mass and function that places individuals at greater risk of disability, loss of independence, and death. Current therapies include addressing underlying performance issues, resistance training, and/or nutritional strategies. However, these approaches have significant limitations, and chronic inflammation associated with sarcopenia may blunt the anabolic response to exercise and nutrition.
View Article and Find Full Text PDFTargeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.
Sci Adv
March 2025
Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known for its role in controlling energy homeostasis, has also been shown to promote tumorigenesis in a range of cancer types, but its role in PC has yet to be explored.
View Article and Find Full Text PDFAugmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept.
Sci Robot
March 2025
NeuroX Institute and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. Here, we developed an implantable spinal cord neuroprosthesis operating in a closed loop to promote robust activity during walking and cycling assisted by robotic devices.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!