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Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility.
J Cereb Blood Flow Metab
March 2025
Department of Physics, Concordia University, Montréal, Québec, Canada.
Cerebrovascular reactivity (CVR) and cerebral pulsatility (CP) are important indicators of cerebrovascular health, which are associated with physical activity (PA). While sex differences influence the impact of PA on cerebrovascular health, sex-specific effects of PA intensity and dose on CP and CVR remains unknown. This study aimed to evaluate the sex-specific effects of self-reported PA dose and intensity on CVR and CP.
View Article and Find Full Text PDFImpact of menopause and age on breast density and background parenchymal enhancement in dynamic contrast-enhanced magnetic resonance imaging.
J Med Imaging (Bellingham)
November 2025
University of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Purpose: Breast density (BD) and background parenchymal enhancement (BPE) are important imaging biomarkers for breast cancer (BC) risk. We aim to evaluate longitudinal changes in quantitative BD and BPE in high-risk women undergoing dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), focusing on the effects of age and transition into menopause.
Approach: A retrospective cohort study analyzed 834 high-risk women undergoing breast DCE-MRI for screening between 2005 and 2020.
Evaluation of the efficacy of injectable platelet-rich fibrin in genitourinary syndrome of menopause.
J Turk Ger Gynecol Assoc
March 2025
Department of Obstetrics and Gynecology, Bolu Abant İzzet Baysal University Faculty of Medicine, Bolu, Türkiye.
Objective: The aim of this study was to investigate the efficacy of injectable, platelet-rich fibrin (PRF) for the treatment of vaginal atrophy, also known as genitourinary syndrome of menopause (GSM), which may affect a third of a woman's lifespan.
Material And Methods: This study included postmenopausal patients who had symptoms of genitourinary syndrome, such as vaginal burning, dryness, itching, and sexual dysfunction. Injectable platelet-rich fibrin (i-PRF) was applied to three areas on the posterior vaginal wall twice, one month apart.
A Novel Formulation Based on Resveratrol and Water Extracts from , , , and Inhibits the Gene Expression of Inflammatory and Osteoclastogenic Biomarkers on C2C12 Cells Exposed to Oxidative Stress.
Foods
March 2025
Botanic Garden "Giardino dei Semplici", Department of Pharmacy, "G. d'Annunzio" University, 66100 Chieti, Italy.
Medicinal plants and natural compounds have been considered alternative therapeutic options for counteracting postmenopausal disorders thanks to their different concomitant effects, including antioxidant and anti-inflammatory properties and the regulation of hormone activity. It is important to highlight that the efficacy of medicinal plants and natural compounds increases when used in combination, thus making the development of herbal formulations rational. Therefore, the present study aimed to evaluate the phytochemical and pharmacological properties of an innovative formulation consisting of resveratrol and water extracts from , , , and .
View Article and Find Full Text PDFBackground: The pathogenesis of female pelvic floor polypropylene mesh complications is unclear as trials evaluating explanted mesh have not included asymptomatic controls.
Objectives: To compare explanted polypropylene mesh from those with and without mesh complications to determine the pathogenesis of the complications.
Methods: Between August 2019 and July 2020 66 participants attending Wesley and Royal Brisbane and Women's Hospital Urogynecology department with mesh complications and 15 undergoing repeat prolapse and/or continence surgery after prior polypropylene mesh implantation were included.
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