A general green protocol for the synthesis of spiro[2.3]hexane avoiding the use of harmful and toxic reagents is described. Spirocyclic scaffolds can be constructed by using alkenes of low reactivity under visible-light irradiation only. Several synthetic advantages of this method are exhibited, including mild conditions, good functional-group tolerance, operational simplicity, and scalability. Mechanistic studies indicate that C-C bond formation occurs almost simultaneously with a light-sustained initiation process.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d5ob00055f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dydrogesterone (DG) is a potent progesterone drug that can be used to treat almost all progesterone-deficiency in women. However, there are few reports on DG process studies, and the by-products are unclear, which make the process optimization challenging. In this paper, we report the process optimization studies for the synthesis of 9α,10β-pregest-5,7-diene-3,20-diethylene glycol ketone (1), an intermediate of DG.
View Article and Find Full Text PDFModular Approach for Photoinduced Cycloaddition Enabling the Synthesis of Diverse Bioactive Oxazoles.
Org Lett
March 2025
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
The synthesis of bioactive oxazoles is often inefficient, and the reported methods remain largely unexplored for complex derivatives. To circumvent this issue, we have utilized a metal-free, photomediated [3 + 2] cycloaddition reaction between diazo compounds and nitriles, leading to a step- and reagent-economical synthesis of bioactive oxazoles. These exciting developments guided us in the efficient synthesis of oxazole-based natural products like annuloline, alkaloids like pimprinethine, labradorin 2, and oxazole-containing pharmaceuticals such as oxaprozin.
View Article and Find Full Text PDFCoupling Strategies of Multi-Physical Fields in 2D Materials-Based Photodetectors.
Adv Mater
March 2025
Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, P. R. China.
2D materials possess exceptional carrier transport properties and mechanical stability despite their ultrathin nature. In this context, the coupling between polarization fields and photoelectric fields has been proposed to modulate the physical properties of 2D materials, including energy band structure, carrier mobility, as well as the dynamic processes of photoinduced carriers. These strategies have led to significant improvements in the performance, functionality, and integration density of 2D materials -based photodetectors.
View Article and Find Full Text PDFSelf-driven charge transfer mechanism of Bi NPs/PCN-224 for enhanced photodynamic antimicrobial chemotherapy effect.
J Colloid Interface Sci
March 2025
School of Petrochemical Technology, Lanzhou University of Technology, Lanzhou 730050, China. Electronic address:
Semiconductor nanomaterials with photocatalytic activity have been identified as a promising class of antimicrobial agents to combat bacterial infections. In this study, a photocatalytic antibacterial and anticancer agent, Bi NPs/PCN-224, was synthesized by doping Bi NPs in PCN-224, obtained through hydrothermal process of porphyrin, using benzoic acid as a morphology modifier. The resulting Bi NPs/PCN-224 exhibited impressive photocatalytic activity with a great potential for therapeutic treatment of bacterial infections.
View Article and Find Full Text PDFPhotoinduced Assembly of Diverse Homoallylic Boronates from -Diborons.
Org Lett
March 2025
Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University, Fuzhou, Fujian 350108, People's Republic of China.
In comparison to alkyl monoboron or 1,2-diboron, which can generate alkyl radicals via tetracoordinate boron species under photocatalytic conditions, the participation of -diborons as substrates in such reactions remains to be developed. Herein, we report a method utilizing -diborons as starting materials to generate α-boryl radicals, which then react with various olefins, successfully and efficiently constructing a diverse range of high-value homoallylic boronates; meanwhile, the -difluorohomoallylic skeletons could also be smoothly obtained. This transformation demonstrates broad substrate scope and excellent tolerance toward functional groups, enhancing the utility of -diboron as precursors for C-C bond construction and the production of valuable products.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!