As significant fungal pathogens of crops, Fusaria species contaminate various food and feed commodities. Some of the spp. secondary metabolites (e.g., trichothecenes, zearalenone, and fumonisins) are widely known toxic molecules (mycotoxins) with chronic and acute effects on humans and animals. The growing demand for safer, pesticide-free food drives us to increase biological control during crop growing. Recent research suggests that lactic acid bacteria (LABs) as biocontrol are the best choice for extenuating mycotoxins. Newly isolated LABs were tested as antifungal agents against , , and . The characterized and genetically identified LABs belonged to (SD4) and (FCW4 and CB2) species. All tested LABs and their cell-free culture supernatants showed antagonism on the MRS solid medium. The antifungal activity was also demonstrated on surface-sterilized wheat and peanuts. The germination test of corn kernels proved that the LAB strains SD4 and FCW4 significantly ( < 0.05) enhanced root and shoot development in plantlets while simultaneously suppressing the outgrowth of . Small-scale corn silage fermentation revealed the significant effects of SD4 supplementation (decreased zearalenone, lower mold count, and total reduction of deoxynivalenol) within the mixed populations.
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http://dx.doi.org/10.3390/toxins17020068 | DOI Listing |
Life Sci
March 2025
Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine of Tsinghua University, Beijing 102218, China; Ministry of Education Key Laboratory of Digital Intelligence Hepatology, Tsinghua University, Beijing 100084, China. Electronic address:
Aims: This study investigates the potential of Bifidobacterium bifidum 1,007,478 (BB478) and its metabolite indole-3-lactic acid (ILA) in alleviating non-alcoholic steatohepatitis (NASH) induced by a high-fat diet (HFD) and fructose exposure.
Materials And Methods: A zebrafish model of NASH was established by exposure to HFD and fructose. BB478 was administered, and the effects on liver lipid accumulation, oxidative stress, and inflammation were assessed.
Int J Biol Macromol
March 2025
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address:
Type 3 resistant starch (RS3) regulates diet-related metabolic diseases by promoting intestinal short-chain fatty acids (SCFAs) and lactate production, and facilitating microbial lactate-to-butyrate fermentation. However, its precise in vivo mechanism remains unclear. Therefore, we studied the effects of type 3 lotus seed resistant starch (LRS3) and sodium lactate (SL) on colonic microbiota composition, metabolism, and lipid parameters.
View Article and Find Full Text PDFImmunity
March 2025
College of Medicine and Health, University of Birmingham, Birmingham, UK. Electronic address:
Lactate, the end product of both anaerobic and aerobic glycolysis in proliferating and growing cells-with the latter process known as the Warburg effect-is historically considered a mere waste product of cell and tissue metabolism. However, research over the past ten years has unveiled multifaceted functions of lactate that critically shape and impact cellular biology. Beyond serving as a fuel source, lactate is now known to influence gene expression through histone modification and to function as a signaling molecule that impacts a wide range of cellular activities.
View Article and Find Full Text PDFMicrobiol Res
March 2025
State Key Laboratory of Plateau Ecology and Agriculture, College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China. Electronic address:
Helicobacter pylori (H. pylori) infection is a highly prevalent causative agent of various gastric diseases. The search for natural alternatives to antibiotics that can effectively inhibit H.
View Article and Find Full Text PDFExplore (NY)
March 2025
Department of Amraze Jild wa Tazeeniyat (Dermatology and Cosmetology), National Institute of Unani Medicine, Bangalore, India.
Introduction: Palmoplantar Keratoderma (PPK) is a heterogeneous group of hereditary and acquired cornification disorders defined by hyperkeratosis of the palms and soles, often resulting in significant discomfort and reduced quality of life. The clinical features include well defined yellowish hyperkeratotic plaques on palm and soles. Treatment typically relies on topical keratolytic agents, including salicylic acid, lactic acid, urea and in more severe cases, systemic therapy with oral retinoids may be required.
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