Seven new (-) and six known (-) statin derivatives were obtained from the deep-sea-derived fungus MCCC 3A00265. The structures assigned to the new compounds were based on a comprehensive analysis of the spectroscopic data, with absolute configurations established by Mosher analysis and biogenetic consideration. Most of the new compounds (- and ) share an octohydronaphthalene backbone, except that viridecalin F () possesses an uncommon naphthalene core. Viridecalins C () and F () and the two known compounds and exhibit considerable ability in reactivating mutant p53 protein at 10 μM, while viridecalin C showcases the most potent reactivation activity, indicating the potential of application in cancer therapy.
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| http://dx.doi.org/10.3390/md23020087 | DOI Listing |
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