Ophthalmic emergencies are acute conditions that progress rapidly, posing a significant threat to a patient's vision and requiring urgent intervention to prevent permanent visual impairment. This study aimed to assess the general awareness of ocular chemical burns and the adequacy of the immediate response measures while also seeking to improve the understanding of these injuries and contribute to promoting a healthier society. A comprehensive literature review was performed, and the most frequently reported questions were incorporated into the original survey. An anonymous questionnaire, available both online and in print, was developed to conduct a cross-sectional study to assess the general knowledge of the causes, symptoms, and appropriate first aid measures to be applied in cases of chemical ocular trauma. Between April and May 2024, 175 individuals completed the questionnaire and were included in the study. More than half (54%) of the tested population demonstrated a poor level of knowledge about chemical ocular injuries, and only 30.9% of the respondents correctly indicated the need for imminent treatment. Twenty percent of the respondents could not identify whether alkalis or acids are more hazardous. Additionally, 5.7% of the respondents falsely considered consultation with an emergency department a priority before thorough irrigation. Most of the respondents (60.6%) incorrectly indicated that the appropriate first aid measures and treatment depend on the substance involved, and 68.1% of the respondents stated that treatment in the emergency department should be delayed, allowing for anamnesis collection and thorough examination. Ocular chemical injuries can substantially impact an individual's quality of life. The present study found that the public knowledge concerning ocular chemical trauma, and the necessary immediate treatment is insufficient. Public education is vital, as delaying prompt and thorough irrigation at the chemical injury site may result in irreversible complications.
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http://dx.doi.org/10.3390/clinpract15020035 | DOI Listing |
NPJ Microgravity
March 2025
Center for Space Medicine, Baylor College of Medicine, Houston, Texas, USA.
In February 1968, NASA purchased 400 antigravity ballpoint pens from the Fisher Pen Company for the Apollo Program to prevent potential harm to astronauts and equipment. Mechanical pencils previously used in microgravity posed risks like eye injuries from floating fragments penetrating the cornea. The cornea is vulnerable to abrasions, perforations, and chemical burns in such environments, affecting crewmembers aboard the International Space Station (ISS).
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March 2025
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
The next-generation gene editing tool, prime editing (PE), is adept at correcting point mutations precisely with high editing efficiency and rare off-target events and shows promising therapeutic value in treating hereditary diseases. Retinitis pigmentosa (RP) is the most common type of inherited retinal dystrophy and is characterized by progressive degeneration of retinal photoreceptors and, consequently, visual decline. To date, effective treatments for RP are lacking.
View Article and Find Full Text PDFFront Med (Lausanne)
February 2025
Biogipuzkoa Health Research Institute, Donostia-San Sebastián, Spain.
Background/aims: Chemical burns to the eye cause extensive ocular surface damage, often resulting in permanent visual impairment. The amniotic membrane (AM), with its regenerative properties, has shown great potential in treating such injuries. Recent innovations, including hydrogel-based delivery systems, have been developed to improve drug retention and promote corneal healing.
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March 2025
Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, 88397, Germany. Electronic address:
Current standard pharmacological treatment of retinal vascular diseases requires frequent intravitreal injection every 4-12 weeks. Active pharmaceutical ingredients (APIs) with better pharmacokinetics (PK), allowing less frequent administrations, remain to be discovered and developed. In preclinical stage mostly small molecule New Chemical Entities (NCEs) and peptides represent promising candidates.
View Article and Find Full Text PDFBMC Immunol
March 2025
Eye School of Chengdu, University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Recent research advancements have enhanced our understanding of the lymphatic system in the eye and nasal region and its involvement in health and disease. The eye is an anatomical extension of the central nervous system and was previously believed to be devoid of lymphatic structures, except for the conjunctiva. However, Lymphatic vessels have been recently identified in the cornea (under pathological conditions), limbus, ciliary body, extraocular muscles, conjunctiva, lacrimal gland, optic nerve sheath, and lymphoid structures in the choroid and Schlemm's duct.
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