Background: Obesity is a serious health issue that affects millions of people worldwide and is associated with a number of comorbid conditions, including gastroesophageal reflux disease. The prevalence of gastroesophageal reflux disease increases with an increase in body mass index; thus, obese patients are at a high risk of developing gastroesophageal reflux disease. The main aim of this study was to determine the frequency of gastroesophageal reflux disease in patients with obesity.
Methods: This descriptive cross-sectional study was carried out at the Gastroenterology Department of Lady Reading Hospital in Peshawar, Pakistan, from June 1, 2023, to December 31, 2023. All obese patients (body mass index >30 kg/m), aged 18-60 years of either sex, with heartburns with or without regurgitation at least three times weekly were included in the study, while patients with a history of esophageal surgery and those with achalasia, scleroderma, esophageal stricture, and esophageal malignancy were excluded from the study.
Results: Among the total 282 obese patients, the majority (53.2%) were women. The mean age was 42.56 years with a standard deviation of 11.4 years. Most of the patients (168, 59.6%) were in the age range of 41-60 years. Seventy-three (25.8%) participants were having gastroesophageal reflux disease.
Conclusion: Gastroesophageal reflux disease is quite common in obese patients. In particular, obese patients with a sedentary or sitting nature of job, older age, high body mass index, and injudicious use of non-steroidal anti-inflammatory drugs and who smoke are at high risk of developing gastroesophageal reflux disease.
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http://dx.doi.org/10.7759/cureus.77921 | DOI Listing |
Clin Chim Acta
March 2025
Department of Medicine, Hunan University of Arts and Science, Changde, Hunan Province 415000, China.
Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy with increasing incidence and poor survival rates, primarily due to late-stage diagnosis. This cancer often develops from Barrett's Esophagus (BE), a precancerous condition linked to chronic gastroesophageal reflux disease (GERD). The transition from BE to EAC is a complex multistep process involving numerous genetic, epigenetic, and molecular changes that lead to the malignant transformation of the esophageal epithelium.
View Article and Find Full Text PDFJ Affect Disord
March 2025
Department of Thoracic Surgery, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou 215101, China. Electronic address:
Background: This study seeks to elucidate the association between depression and the risk of chronic obstructive pulmonary disease (COPD) by Mendelian randomization (MR) analysis, motivated by prior observational studies indicating a potential link between these conditions.
Methods: Data from individuals of European (EUR) and East Asian (EAS) ancestries diagnosed with major depressive disorder (MDD) were selected for analysis. The primary method utilized was inverse variance weighted (IVW) method, supplemented by a series of sensitivity analyses and false discovery rate (FDR) corrections.
ANZ J Surg
March 2025
Department of Surgery, University of Notre Dame Australia, Sydney, New South Wales, Australia.
Background: Gastroesophageal reflux disease (GORD) is a significant problem after laparoscopic sleeve gastrectomy (SG). This study aimed to assess the long-term effect of SG with an anterior fundoplication on GORD symptoms.
Methods: A single-centre cohort study of all patients who underwent SG with anterior hemifundoplication (SGAF), with a 2:1 SG only comparison group.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of ENT, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Pillaiyarkuppam, Pondicherry, 607402 India.
Laryngopharyngeal reflux disease (LPRD) is characterized by the backflow of gastric contents into the laryngopharynx, distinct from gastroesophageal reflux disease (GERD). Prevalence among otolaryngology patients ranges from 4 to 30% and being the major cause for hoarseness of voice. Common symptoms include hoarseness, chronic coughing, globus sensation, throat clearing and endoscopic evaluation reveals signs like posterior commissure hypertrophy and vocal fold edema.
View Article and Find Full Text PDFJ Formos Med Assoc
March 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, An Nan Hospital, China Medical University, Tainan, Taiwan. Electronic address:
Background: Whether continuous proton pump inhibitor (PPI) therapy is superior to on-demand therapy for symptom control of Barrett's esophagus patients is unclear. The study aimed to compare the efficacies of the symptom control and the frequency of co-existent erosive esophagitis in patients with Barrett's esophagus by either continuous or on-demand PPI therapy.
Methods: We randomly assigned (1:1) consecutive adult patients with symptomatic Barrett's esophagus to receive on-demand or continuous esomeprazole (40 mg q.
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