In this case report, a 69-year-old man with a 25-year history of type 2 diabetes mellitus was admitted with severe symptoms like flank pain radiating to the groin, high-grade fever, hematuria, and respiratory symptoms, including shortness of breath and a productive cough. After a complete evaluation, he was diagnosed with emphysematous pyelonephritis (EPN), and to treat this condition, the patient underwent a surgery called percutaneous nephrolithotomy (PCNL), which is used to remove kidney calculi. EPN is a condition characterized by severe infection of the kidney tissue. After the surgery, the patient started experiencing respiratory distress, due to which he was referred to the cardiorespiratory physiotherapy department for further treatment. On the initial assessment, it was found that he had respiratory complications like reduced chest expansion, crackles heard in the lower part of his left lung, and moderate to severe breathlessness (Modified Medical Research Council grade III). A two-week physiotherapy program was planned for the patient, which focused on managing pain, improving chest expansion, clearing the airways, and increasing overall mobility. A few physiotherapy interventions were used, such as transcutaneous electrical nerve stimulation (TENS), deep breathing exercises, the active cycle of breathing technique, and early mobilization. After two weeks of rehabilitation, there was increased chest expansion and reduced shortness of breath and pain. He could also walk during the six-minute walk test (6MWT), which showed improved functional capacity. This case highlights the vital role of early physiotherapy in managing post-surgical complications and promoting early recovery in patients who have undergone PCNL surgery for EPN.
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http://dx.doi.org/10.7759/cureus.77967 | DOI Listing |
EFORT Open Rev
February 2025
Alkaptonuria is an extremely rare disorder of tyrosine metabolism caused by an autosomal recessive enzymatic deficiency of homogentisic acid (HGA) oxidase, causing its accumulation in collagenous structures, especially in hyaline cartilage. It is characterized by a triad of homogentisic aciduria, bluish-black discoloration of connective tissues (ochronosis) and arthropathy of the spine and large weight-bearing joints. Several clinical manifestations were described including coronary and valvular calcification, aortic stenosis, limited chest expansion, and renal, urethral and prostate calculi as well as ocular and cutaneous pigmentation.
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March 2025
Department of Critical Care Medicine and Emergency, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cardiac dysfunction is a serious complication of sepsis-induced multiorgan failure in intensive care units and is characterized by an uncontrolled immune response to overwhelming infection. Type 2 innate lymphoid cells (ILC2s), as a part of the innate immune system, play a crucial role in the inflammatory process of heterogeneous cardiac disorders. However, the role of ILC2 in regulating sepsis-induced cardiac dysfunction and its underlying mechanism remain unknown.
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Physical Therapy, Clear Life Scoliosis Reduction and Chiropractic, Huntersville, USA.
Adolescent idiopathic scoliosis (AIS) is a complex spinal deformity that affects millions of people worldwide. Severe scoliosis is thought to be progressive. This case study examines the benefits of a comprehensive, non-surgical treatment protocol developed by the Chiropractic Leadership, Educational Advancement, and Research (CLEAR) Institute.
View Article and Find Full Text PDFJTCVS Open
February 2025
Division of Thoracic Surgery, Sant'Andrea Hospital, Sapienza University, Rome, Italy.
Objective: Prolonged air leak due to residual air space after lung resection is a main challenge. To date, few surgical options have been described to prevent this complication. The aim of this study is to investigate the safety and the efficacy of intraoperative phrenic nerve infiltration with long-acting anesthetics in producing transient hemidiaphragm paralysis in patients at high risk for prolonged air leak, thus improving pulmonary expansion after surgery and reducing air leaks, while controlling postoperative pain.
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March 2025
Institute of Pharmacology, West-German Heart and Vascular Centre, University Duisburg-Essen, Essen, Germany.
Despite substantial advances in cardiovascular pharmacotherapy and devices in recent years, prevention and treatment of many cardiovascular diseases (CVD) remain limited, thus reflecting the need for more effective and safer pharmacological strategies. In this review, we summarize the most relevant studies in cardiovascular pharmacotherapy in 2024, including the approval of first-in-class drugs for the treatment of resistant hypertension and pulmonary arterial hypertension, label expansions for bempedoic acid and semaglutide, and the results of major randomised clinical trials (RCTs) that have met the prespecified primary endpoints, thereby filling some gaps in knowledge and opening new perspectives in the management of CVD, and those RCTs whose results did not confirm the proposed research hypotheses. We also include a section on drug safety, where we describe the newest data on adverse reactions and drug-drug interactions that may complicate treatment and/or reduce drug adherence with the consequent decrease in drug effectiveness.
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