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http://dx.doi.org/10.21037/qims-24-945 | DOI Listing |
Comp Biochem Physiol A Mol Integr Physiol
March 2025
Department of Biological Sciences, California State University San Marcos, CA 92096, USA. Electronic address:
Salmonid fishes are well adapted to transition between salinities as part of a diadromid lifestyle, and many species are both economically and environmentally important. Ion-transporting gill epithelium helps fishes maintain ion balance during salinity transition. Recent transcriptomic surveys suggest that voltage-gated ion channels (VGICs) are present in gill epithelium of fishes.
View Article and Find Full Text PDFGan To Kagaku Ryoho
February 2025
Dept. of Surgery, Kinki Central Hospital.
A male in his 80s with a history of multiple colorectal cancer resections underwent an upper gastrointestinal endoscopy for anemia investigation, which revealed a non-ampullary duodenal carcinoma. Due to insufficient surgical tolerance for pancreaticoduodenectomy, pharmacotherapy was considered. With informed consent, an MSI test was conducted, showing MSI-high, leading to the initiation of pembrolizumab treatment.
View Article and Find Full Text PDFAm J Hum Genet
March 2025
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Genome-wide association studies have been highly successful at identifying common variants associated with cancer; however, they do not explain all the inherited risks of cancer. Family-based studies, targeted sequencing, and, more recently, exome-wide association studies have identified rare coding variants in some genes associated with cancer risk, but the overall contribution of these variants to the heritability of cancer is less clear. Here, we describe a method to estimate the genome-wide contribution of rare coding variants to heritability that fits models to the burden effect sizes using an empirical Bayesian approach.
View Article and Find Full Text PDFMar Pollut Bull
March 2025
Laoshan Laboratory, Qingdao 266237, China; College of Ocean Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China. Electronic address:
The combined impact of multiple human activities is the primary driver of coastal ecosystem degradation, and comprehending its mechanisms is essential for developing adaptive management strategies. A coastal ecosystem model coupling multiple human activities, including runoff discharge, reclamation, mariculture, and atmospheric deposition, was developed using the Regional Ocean Modeling System (ROMS) coupled with the Carbon, Silicate, and Nitrogen Ecosystem (CoSiNE) model. The model performance was rigorously evaluated in the Bohai Sea as the study area.
View Article and Find Full Text PDFHealthc Manage Forum
March 2025
University of Ottawa, Ottawa, Ontario, Canada.
Registered Dietitians (RDs) are essential professionals within Canadian Team-Based Primary Care (TBPC). RDs utilize practice competencies to ensure provision of high-quality care while working closely with other TBPC members. To fill in the gaps in the literature, the study's objective was to explore RDs' perception of their contributions to TBPC settings and their educational needs.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!