Gestational malaria is a life-threatening disease that affects pregnant women in endemic regions. Infection with parasites of the genus Plasmodium, transmitted by infected mosquitoes, can trigger complications for the mother and fetus. We present the description of a clinical case of gestational malaria complicated by in a 25-year-old multiparous patient in the third trimester of pregnancy from an endemic area in the department of Córdoba, Colombia. Admission to the intensive care unit for 3 days and an emergency cesarean section were necessary due to serious complications, such as anemia, severe thrombocytopenia, and hypertensive symptoms. Treatment included the use of chloroquine and red blood cell and platelet transfusions to address hematologic complications. After the cesarean section, the patient made a satisfactory recovery and was prescribed primaquine for 14 days. The importance of surveillance and adequate management of gestational malaria is highlighted to prevent serious complications during pregnancy and in the postpartum period. This clinical case highlights the complexity of gestational malaria and the need for a comprehensive approach to its management, with special attention to hematologic, hypertensive, and obstetric complications that may arise in this clinical context.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848752 | PMC |
http://dx.doi.org/10.1016/j.ijregi.2025.100586 | DOI Listing |
BMC Pregnancy Childbirth
March 2025
Department of Nursing and Midwifery, Valley View University, Kumasi, Ghana.
Background: Malaria is a life-threatening disease, and in pregnancy, it has been recognized to pose a substantial threat to mothers, fetuses and neonates and accounted for 249 million malaria cases and 608,000 malaria deaths in 85 countries in 2022. Malaria in pregnancy poses a significant threat, and globally, it is associated with approximately 10,000 maternal deaths each year. In sub-Saharan Africa, it is projected that approximately 25 million pregnant women in this region are at risk of contracting Plasmodium falciparum malaria infection annually.
View Article and Find Full Text PDFEpigenetics
December 2025
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Fetal growth restriction (FGR) is associated with perinatal death and adverse birth outcomes, as well as long-term complications, including increased childhood morbidity, abnormal neurodevelopment, and cardio-metabolic diseases in adulthood. Placental epigenetic reprogramming associated with FGR may mediate these long-term outcomes. Placental malaria (PM), characterized by sequestration of -infected erythrocytes in placental intervillous space, is the leading global cause of FGR, but its impact on placental epigenetics is unknown.
View Article and Find Full Text PDFPLoS Med
March 2025
Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Background: Malaria in pregnancy detected by microscopy is associated with maternal anaemia, reduced fetal growth, and preterm birth, but the effects of lower density (i.e., submicroscopic) malaria infections are poorly characterised.
View Article and Find Full Text PDFBackground: Active surveillance involves systematically monitoring patients to seek detailed information about the occurrence of adverse events (AEs) following drug administration. The Seta technology was developed to improve active surveillance of AEs or pregnancy in low- and middle-income countries and geographically challenging areas. Seta actively solicits responses from participants via WhatsApp messages.
View Article and Find Full Text PDFPediatr Res
March 2025
ICMR-National Institute of Malaria Research, 110077, New Delhi, India.
Background: Malaria during pregnancy can have adverse effects on fetal development, but its impact on neurodevelopment remains unclear. Although some studies have explored the consequences of prenatal malaria, gaps persist due to inconsistencies in exposure timing, assessment methods, and study designs.
Methods: This systematic review highlighted the gaps in six studies selected from an initial pool of 2029 articles, offering clearer insights into the neurodevelopmental outcomes of prenatal malaria exposure.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!