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| http://dx.doi.org/10.3389/fphar.2025.1552652 | DOI Listing |
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Predictive biomarkers for the efficacy of PARP inhibitors in ovarian cancer: an updated systematic review.
BJC Rep
March 2025
Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Background: PARP inhibitors are effective in treating ovarian cancer, especially for BRCA1/2 pathogenic variant carriers and those with HRD (homologous recombination deficiency). Concerns over toxicity and costs have led to the search for predictive biomarkers. We present an updated systematic review, expanding on a previous ESMO review on PARP inhibitor biomarkers.
View Article and Find Full Text PDFMalleatin A and B: New Premyrsine-Type Diterpenes from with Cytotoxic Effects Against A2780 Wild and A2780 R-CIS Ovarian Cancer Cell Lines in Mono or Combination Treatment with Cisplatin.
Iran J Pharm Res
November 2024
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: This study focused on macrocyclic diterpenes derived from Euphorbia, particularly myrsinanes, and their potential in cytotoxic and combination treatments for resistant cancer cells. We examine premyrsinanes isolated from and explore their cytotoxic properties.
Methods: was collected from Taragh-Roud, Natanz, Iran.
Role of RGS17 in cisplatin-induced cochlear inflammation and ototoxicity via caspase-3 activation.
Front Immunol
March 2025
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, United States.
Cisplatin is a chemotherapy drug used to treat different solid tumors, including ovarian, bladder, lung, and head and neck cancers. One of its significant side effects is ototoxicity, especially when high doses are required. Cisplatin-induced ototoxicity is associated with increased cochlear cell death resulting from DNA damage, caspase activation, oxidative stress, inflammation, and glutamate excitotoxicity.
View Article and Find Full Text PDFHigh-grade serous ovarian carcinoma (HGSOC) is one of the deadliest malignancies in female population and the cause of 70% of all ovarian cancer-related deaths. Among its hallmarks, the fluid accumulation in the peritoneal cavity, or ascites, is a peculiar pathological sign during late stages and in recurrent patients. Besides cancer cells, ascitic fluids contain a heterogeneous cellular composition, representing a precious source to dissect molecular mechanisms underlying invasion and metastatization or find new biomarkers to predict therapy response.
View Article and Find Full Text PDFMenopause part I: Vasomotor symptoms (I).
Taiwan J Obstet Gynecol
March 2025
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Female Cancer Foundation, Taipei, Taiwan; Department of Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan. Electronic address:
Menopause, an aged process due to loss of permanent ovarian function (mainly decreased production of estrogen) without another pathological or physiological cause becomes one of the most health issues in the world. Vasomotor symptoms (VMS) is a hallmark of menopause, occurring in up to 80 % of women experiencing and persisting for over seven years with significant negative impacts on physical, psychological, social, and overall wellbeing. Conventionally, menopause hormone therapy (MHT) is considered the most effective therapeutic opinion for many years based on the fact as "deficiency of estrogen"; however, the ratio of benefits and risk is highly debated and always in concern.
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