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Efferocytosis and retinal clean-up: role of histone deacetylase 3 in ischemic retinopathy.
Neural Regen Res
February 2025
Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA (Fouda AY, Shosha E).
Role of RPE Phagocytosis in the Retina Metabolic Ecosystem.
Adv Exp Med Biol
February 2025
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Photoreceptors are the most glycolytically active cells in the body. Vital to glucose homeostasis is the metabolic relationship between the photoreceptors and the retinal pigment epithelium (RPE). The photoreceptors and RPE are in metabolic symbiosis, wherein the RPE takes up glucose from circulation and passes it on to the photoreceptors to fuel glycolysis.
View Article and Find Full Text PDFDeletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury.
J Neuroinflammation
July 2024
Department of Pharmacology and Toxicology College of Medicine, University of Arkansas for Medical Sciences (UAMS), 4301 West Markham Street, Slot 611, BIOMED-1, B306, Little Rock, Office, AR, 72205, USA.
Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and central retinal artery and vein occlusions. Treatments for ischemic retinopathies fail to improve clinical outcomes and the design of new therapies will depend on understanding the underlying disease mechanisms. Histone deacetylases (HDACs) are an enzyme class that removes acetyl groups from histone and non-histone proteins, thereby regulating gene expression and protein function.
View Article and Find Full Text PDFIntercellular contact and cargo transfer between Müller glia and to microglia precede apoptotic cell clearance in the developing retina.
Development
January 2024
Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.
To clarify our understanding of glial phagocytosis in retinal development, we used real-time imaging of larval zebrafish to provide cell-type specific resolution of this process. We show that radial Müller glia frequently participate in microglial phagocytosis while also completing a subset of phagocytic events. Müller glia actively engage with dying cells through initial target cell contact and phagocytic cup formation, after which an exchange of the dying cell from Müller glia to microglia often takes place.
View Article and Find Full Text PDFClearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: Molecular mechanisms and relation to retinal inflammation.
Immunol Rev
October 2023
Center for Cancer, Genetic Diseases and Gene Regulation, Department of Biological Sciences, Fordham University, Bronx, New York, USA.
Mammalian photoreceptor outer segment renewal is a highly coordinated process that hinges on timed cell signaling between photoreceptor neurons and the adjacent retinal pigment epithelial (RPE). It is a strictly rhythmic, synchronized process that underlies in part circadian regulation. We highlight findings from recently developed methods that quantify distinct phases of outer segment renewal in retinal tissue.
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