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| http://dx.doi.org/10.1038/s41377-025-01765-6 | DOI Listing |
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The causal effects of inflammatory bowel disease on its ocular manifestations: A Mendelian randomization study.
PLoS One
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Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background: Observational studies have shown that ocular manifestations of inflammatory bowel disease (IBD) are common extraintinal manifestations, among which iridocyclitis, scleritis and episcleritis are the most common. However, whether there is a causal relationship between the two is unclear. The purpose of this study was to evaluate the causality of IBD on ocular manifestations using the mendelian randomization (MR) analysis.
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Biology Department, Mount Saint Vincent University, Halifax, Canada.
The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule-associated protein required for correct mitotic spindle formation. To better understand the contribution of Asp to microtubule organization during spindle formation, we reverse-engineered flies to express a version of Asp (Asp), predicted to have lost its ability to bind the phosphatase trimer PP2A-B56.
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The pBMN-I-GFP plasmid is a widely used retroviral vector for producing retroviral particles, utilized by thousands of laboratories worldwide. However, we observed that E. coli transformed with pBMN-I-GFP failed to grow on selective LB agar plates containing ampicillin or carbenicillin, in contrast to similar retroviral vectors.
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The Fukui function and its associated potential serve as essential descriptors of chemical reactivity within the framework of conceptual density functional theory (c-DFT). While c-DFT is well-established for molecular systems, it encounters formal and technical challenges when applied to extended systems. This comprehensive study addresses the complexities involved in calculating the Fukui function and its potential in systems with periodic boundary conditions (PBC).
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