A review of chitosan-based multifunctional nanocomposites for drug/gene/protein delivery and gene therapy in cancer treatments: Promises, challenges and outlooks.

This study provides a comprehensive examination of chitosan-based multifunctional nanocomposites and their extensive applications in drug/gene/protein delivery, tissue engineering and cancer therapy. As a natural polymer with eco-friendly characteristics and both antimicrobial and anti-cancer properties, chitosan has garnered attention in numerous medical and pharmaceutical domains. The research explores diverse chitosan nanocomposites, including those incorporating magnetic nanoparticles, carbon nanotubes, and clay- and alginate-based nanocomposites. Additionally, the study addresses the obstacles encountered in developing these materials and their potential for creating advanced drug delivery systems and targeted treatments. The study highlights the applications of these nanocomposites in bone, cartilage, and skin tissue regeneration, as well as their potential in neural tissue engineering. in conclusion, the research underscores the promising future of chitosan-based nanocomposites in revolutionizing drug delivery, tissue engineering, and cancer therapy. It emphasizes the need for further studies to fully harness the potential of these materials and translate laboratory findings into clinical applications, paving the way for more effective and personalized medical treatments. Our reason for writing this article appears to be a comprehensive exploration of the potential and challenges of chitosan-based multifunctional nanocomposites in medicine, particularly in drug/gene/protein delivery and cancer therapy. The aim is to provide a detailed analysis of the material's versatility, its integration with advanced nanotechnologies, and its applications in targeted treatments, and regenerative medicine. we seek to address existing challenges, such as safety, scalability, and regulatory compliance, while highlighting the promising future of these materials in personalized and efficient medical treatments.