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Efficacy and safety of medroxyprogesterone acetate on noninvasive ventilation -treated exacerbated COPD patients: a double-blind randomized clinical trial.
BMC Pulm Med
March 2025
Department of Clinical Pharmacy, School of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Background: In acute exacerbation periods of chronic obstructive pulmonary disease (COPD), patients may experience hypoxemia or hypercapnia. Noninvasive ventilation (NIV) and respiratory stimulant drugs are used to treat this condition. Medroxyprogesterone acetate (MPA) can cross the blood-brain barrier and cause breathing stimulation and hyperventilation.
View Article and Find Full Text PDFHormonal and metabolic responses across phases of combined oral contraceptive use and menstrual cycle in young elite female athletes.
Eur J Appl Physiol
March 2025
CIAMS, Université d'Orléans, Pôle STAPS, Orléans, France.
Purpose: Despite the significant number of female athletes using combined oral contraceptives (COCs), there is scant literature on their hormonal and metabolic effects across different phases.
Methods: In order to contribute to a wider knowledge of COC-action mechanisms involved in athletes' performance and health, we therefore examined the effects of low-dose monophasic COC (ethinylestradiol/levonorgestrel) intake on sex hormones (estradiol, progesterone, sex hormone binding protein (SHBG)) as well as on a large number of pituitary (LH, TSH, prolactin) and peripheral (triiodothyronine, cortisol, DHEA, DHEA-S, aldosterone, osteocalcin, 25(OH)D) basal hormone levels in nine young elite female athletes, across COC administration (first and second half of active hormone intake, washout phases), compared to eleven female athletes without hormonal contraception across their normal menstrual cycle (NMC, i.e.
Effects of Vaginal vs. Oral Progesterone Supplementation Before Embryo Transfer on Live Birth Rates and Levels: A Randomized Trial.
Reprod Fertil
March 2025
J Barrenetxea, Gynecology, Reproducción Bilbao Assisted Reproduction Center, Bilbao. Spain , Bilbao, Spain.
The increase in frozen embryo transfers is a consequence of advances in embryo vitrification and the implementation of genetic screening of embryos. There is debate over the best progesterone administration route in substituted cycles and the relationship between progesterone levels on embryo transfer day and reproductive outcomes. This trial aimed to compare the clinical results of different progesterone supplementation schedules before embryo transfer and assess the relationship between plasmatic progesterone levels on transfer day and clinical outcomes.
View Article and Find Full Text PDFDietary supplements typically contain either natural products or synthetic chemicals. While botanical dietary supplements are often thought to be more natural and safer, they could still contain potentially harmful ingredients. Despite the detection of sex hormones in plants and soil, it is still worth examining if products made from plants contain them.
View Article and Find Full Text PDFThe see-saw effect of neuroactive steroids and endocrine disrupting compounds on maternal mental health status.
Neurotoxicology
March 2025
Department of Psychiatry, SRM Medical College Hospital and Research Centre, Chengalpattu Dt, Kattankulthur, Tamil Nadu 603203, India. Electronic address:
Background: Antepartum depression, a non-psychotic mood disturbance occurring during pregnancy, is influenced by hormonal fluctuations and environmental endocrine disruptors. Despite its association with adverse postpartum outcomes, it has been studied to a limited extent. Hence, this study aims to investigate the association of neuroactive steroids, endocrine-disrupting compounds, and nutritional status of pregnant women with the manifestations of antepartum depressive symptoms.
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